Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single doses.
Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single doses.
复制标题
DOI：
10.1093/jrr/rrs089
复制
发表时间：
2013-03-01
影响因子：
2
通讯作者：
Shibamoto Y
中科院分区：
文献类型：
--
作者：
Iwata H;Matsufuji N;Toshito T;Akagi T;Otsuka S;Shibamoto Y
我们研究了可修复-有条件可修复（RCR）模型和多靶点（MT）模型与线性二次（LQ）模型在高剂量率放疗剂量转换中的适用性。分析了接受2-12戈伊单次剂量或2次或3次（每次4或5戈伊）的V79和EMT 6单细胞的细胞存活数据，以及接受5-26戈伊单次剂量或2-5次（每次5-12戈伊）的V79球状体的细胞存活数据。通过集落测定确定实际上将细胞存活降低至相同水平的单次和分次剂量。在计算软件Mathematica中，将实验中使用的单剂量和剂量下的存活分数代入RCR、MT和LQ模型的方程中，并计算每个参数系数。此后，使用系数和三种模型，计算大分割剂量的等效单次剂量。然后将其与实际确定的低分次剂量的等效单次剂量进行比较。使用RCR、MT和LQ模型计算的等效单次剂量往往低于实际测定的等效单次剂量。LQ模型在5戈伊或更低剂量时拟合较好，在6戈伊或更高剂量时，RCR和MT模型比LQ模型更可靠。在大分割立体定向放射治疗中，不应使用LQ模型，而转换模型，如广义线性二次模型，结合RCR或MT模型的概念，似乎更合适。
We investigated the applicability of the repairable-conditionally repairable (RCR) model and the multi-target (MT) model to dose conversion in high-dose-per-fraction radiotherapy in comparison with the linear-quadratic (LQ) model. Cell survival data of V79 and EMT6 single cells receiving single doses of 2–12 Gy or 2 or 3 fractions of 4 or 5 Gy each, and that of V79 spheroids receiving single doses of 5–26 Gy or 2–5 fractions of 5–12 Gy, were analyzed. Single and fractionated doses to actually reduce cell survival to the same level were determined by a colony assay. Single doses used in the experiments and surviving fractions at the doses were substituted into equations of the RCR, MT and LQ models in the calculation software Mathematica, and each parameter coefficient was computed. Thereafter, using the coefficients and the three models, equivalent single doses for the hypofractionated doses were calculated. They were then compared with actually-determined equivalent single doses for the hypofractionated doses. The equivalent single doses calculated using the RCR, MT and LQ models tended to be lower than the actually determined equivalent single doses. The LQ model seemed to fit relatively well at doses of 5 Gy or less. At 6 Gy or higher doses, the RCR and MT models seemed to be more reliable than the LQ model. In hypofractionated stereotactic radiotherapy, the LQ model should not be used, and conversion models incorporating the concept of the RCR or MT models, such as the generalized linear-quadratic models, appear to be more suitable.
登录
查看更多内容
影响因子：
6.2
作者：
Chang, Daniel T.;Swaminath, Anand;Schefter, Tracey E.
通讯作者：
Schefter, Tracey E.
DOI：
10.1016/j.ijrobp.2008.12.093
发表时间：
2009-10-01
影响因子：
7
作者：
Iwata, Hiromitsu;Shibamoto, Yuta;Ito, Masato
通讯作者：
Ito, Masato
影响因子：
1.9
作者：
Kondziolka, Douglas;Flickinger, John C.;Lunsford, L. Dade
通讯作者：
Lunsford, L. Dade
影响因子：
3.4
作者：
ELKIND, MM;SUTTON, H
通讯作者：
SUTTON, H
影响因子：
3.4
作者：
Lind, BK;Persson, LM;Brahme, A
通讯作者：
Brahme, A