Exposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the level of sweet taste most preferred among 4-to 6-year-old Ghanaian children: follow-up of a randomized controlled trial
Exposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the level of sweet taste most preferred among 4-to 6-year-old Ghanaian children: follow-up of a randomized controlled trial
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DOI：
10.1093/ajcn/nqy352
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发表时间：
2019-04-01
影响因子：
7.1
通讯作者：
Dewey, Kathryn G.
中科院分区：
文献类型：
--
作者：
Okronipa, Harriet;Arimond, Mary;Dewey, Kathryn G.
背景：生命早期喂养微甜营养补充剂对以后甜味偏好的影响尚不清楚。目的：我们测试了这样的假设：生命早期接触过微甜脂质营养补充剂 (LNS) 的 4-6 岁儿童最喜欢的蔗糖水平不会高于从未接触过 LNS 的儿童。设计：我们对参加加纳一项随机试验的妇女 (n = 1,320) 所生的孩子进行了随访。在一组中，在怀孕期间和产后前 6 个月内每天向妇女及其 6 至 18 个月的婴儿（LNS 组）提供 LNS。对照组在怀孕期间和产后前 6 个月每天接受铁和叶酸或多种微量营养素，不补充婴儿补充剂（非 LNS 组）。在 4-6 岁时，我们随机选择了儿童子样本 (n = 775)，以使用莫内尔 2 系列、强制选择、配对比较跟踪程序来评估最优选的蔗糖浓度。我们使用 5% 重量/体积 (wt/vol) 的非劣效裕度比较了 LNS 与非 LNS 组的差异。结果：在接受测试的 624 名儿童中，大多数 (61%) 提供了可靠的反应。在所有儿童中，最优选的平均+/-SD蔗糖溶液（%重量/体积）为14.6+/-8.6（LNS组14.9+/-8.7；非LNS组14.2+/-8.4）。然而，在有可靠反应的儿童中，该值为 17.0 +/- 10.2（LNS 组 17.5 +/- 10.4；非 LNS 组 16.5 +/- 10.0）。无论是在完整样本中还是在有可靠反应的样本中，组间差异的 95% CI 上限均未超过非劣效界，表明 LNS 组并不比非 LNS 组具有更高的甜味偏好。结论：生命早期接触微甜营养补充剂并没有增加儿童时期最偏好的甜味水平。
Background: The impact of feeding a slightly sweet nutrient supplement early in life on later sweet taste preference is unknown.Objective: We tested the hypothesis that the level of sucrose most preferred by 4-6-y-old children exposed to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not be higher than that of children never exposed to LNS.Design: We followed up children born to women (n = 1,320) who participated in a randomized trial in Ghana. In one group, LNS was provided to women on a daily basis during pregnancy and the first 6 mo postpartum and to their infants from age 6 to 18 mo (LNS group). The control groups received daily iron and folic acid or multiple micronutrients during pregnancy and the first 6 mo postpartum, with no infant supplementation (non-LNS group). At age 4-6 y, we randomly selected a subsample of children (n = 775) to assess the concentration of sucrose most preferred using the Monell 2-series, forced-choice, paired-comparison tracking procedure. We compared LNS with non-LNS group differences using a noninferiority margin of 5% weight/volume (wt/vol).Results: Of the 624 children tested, most (61%) provided reliable responses. Among all children, the mean +/- SD sucrose solution most preferred (% wt/vol) was 14.6 +/- 8.6 (LNS group 14.9 +/- 8.7; non-LNS group 14.2 +/- 8.4). However, among children with reliable responses, it was 17.0 +/- 10.2 (LNS group 17.5 +/- 10.4; non-LNS group 16.5 +/- 10.0). The upper level of the 95% CI of the difference between groups did not exceed the noninferiority margin in either the full sample or those with reliable responses, indicating that the LNS group did not have a higher sweet preference than the non-LNS group.Conclusion: Exposure to a slightly sweet nutrient supplement early in life did not increase the level of sweet taste most preferred during childhood.