Rapid increases of gamma power in the auditory cortex following noise trauma in humans
Rapid increases of gamma power in the auditory cortex following noise trauma in humans
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DOI：
10.1111/j.1460-9568.2010.07542.x
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发表时间：
2011-02-01
影响因子：
3.4
通讯作者：
Weisz, Nathan
中科院分区：
文献类型：
--
作者：
Ortmann, Magdalene;Mueller, Nadia;Weisz, Nathan
耳鸣是在没有任何外部声源的情况下的听觉感知。耳鸣的发生与听觉皮层神经元活动的同步性增强有关。通常可以识别听力损伤，这表明中央听觉区域的听觉剥夺是与耳鸣相关的神经生理过程的基础。到目前为止，人类研究已经进行了慢性耳鸣患者（> 6个月）。然而，伴随听觉剥夺和脓毒性耳鸣的神经元活动可能不会随着时间的推移而保持恒定，使得难以将当前动物研究（急性耳鸣）的结果与人类慢性耳鸣直接相关，反之亦然。我们调查了14名业余摇滚音乐家，他们经常在乐队练习后立即报告短期耳鸣。在两个不同的场合进行脑磁图静息状态记录，听力测定和耳鸣测试：有和没有以前暴露于响亮的音乐。分析显示，14例中有13例一过性耳鸣伴有双耳暂时性听力损失和右侧听觉皮层γ活动增加。耳鸣与听力损失有密切关系。与动物研究类似，我们的研究结果首次在人类身上表明，噪音创伤会迅速导致听觉皮层神经元同步性的增加。重要的是，强烈的右侧效应意味着它并不反映耳鸣本身。这可能是由左耳特别明显的高频听力损失的更大不连续性引发的。
Tinnitus is an auditory perception in the absence of any external sound source. It has been suggested that tinnitus is related to enhanced synchronization of neuronal activity in the auditory cortex. Usually a hearing damage can be identified suggesting auditory deprivation to central auditory regions to be fundamental for neurophysiological processes related to tinnitus. Until now, human research has been conducted on patients with chronic tinnitus (> 6 months). However, neuronal activity accompanying auditory deprivation and putatively tinnitus may not remain constant over time, making it difficult to directly relate outcomes of current animal studies (acute tinnitus) to chronic tinnitus in humans, and vice versa. We investigated 14 amateur rock musicians who frequently reported a short-term tinnitus immediately after band practice. Magnetoencephalographic resting-state recordings, audiometry and tinnitus testing were performed at two separate occasions: with and without previous exposure to loud music. Analyses revealed that transient tinnitus was accompanied by temporary hearing loss in both ears and increased gamma activity in the right auditory cortex in 13 out of 14 cases. Additionally, tinnitus frequency was strongly correlated to hearing loss. Analogous to animal studies, our results show for the first time in humans that noise trauma leads rapidly to increased neuronal synchrony in the auditory cortex. Importantly, the strongly right-lateralized effect implies that it does not reflect tinnitus percept per se. This could rather have been triggered by greater discontinuities of hearing loss at high frequencies that were particularly pronounced in the left ear.