Histamine-immunoreactive nerve fibers in the rat pineal gland: evidence for a histaminergic central innervation
Histamine-immunoreactive nerve fibers in the rat pineal gland: evidence for a histaminergic central innervation
复制标题
大鼠松果体中的组胺免疫反应性神经纤维：组胺能中枢神经支配的证据
DOI：
10.1016/0006-8993(92)91475-t
复制
发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
M. Møller
中科院分区：
文献类型：
--
作者：
J. Mikkelsen;P. Panula;M. Møller
以碳二亚胺为固定剂，用抗组胺血清免疫组织化学方法，研究了组胺在大鼠松果体复合体中的定位。在下丘脑后结节乳头核的不同亚区内可见大量的组胺免疫反应阳性细胞体，在下丘脑室旁核的后部和背侧部也有少量的组胺免疫反应胞体。观察到组胺免疫反应纤维从不同方向离开下丘脑后部，其中一条背侧投射束在间脑尾侧脑室周区向上皮层投射。该束的几个组胺免疫反应神经纤维通过后连合直接进入松果体深层。缰核连合内也可见少量免疫反应纤维。在正中矢状面，观察到组胺免疫反应神经纤维从松果体深层进入松果体柄。茎内的组胺免疫反应纤维主要分布在松果体的浅部，但在茎的较远端部位数量减少，表明部分纤维也终止于柄内。少数纤维终止于松果体浅层最上端。上皮层和松果体复合体内的免疫反应神经纤维呈明显的曲张。综上所述，这些结果表明组胺能神经纤维。起源于下丘脑后部，投射到大鼠的松果体复合体。因此，组胺必须被认为是松果体中枢神经支配中的一种假定的神经递质，但它在松果体生理学中的作用迄今尚未阐明。
An immunohistochemical method that utilizes carbodiimide as a fixative and antisera directed against histamine was applied to investigate the location of histamine in the rat pineal complex. Numerous histamine-immunoreactive cell bodies were observed in different subdivisions of the tuberomammillary nucleus of the posterior hypothalamus, and a few cell bodies were present in the posterior and dorsal part of the periventricular hypothalamic nucleus. Histamine-immunoreactive fibers were observed to leave the posterior hypothalamus in various directions of which one dorsally projecting tract was followed in the periventricular area of the caudal diencephalon to the epithalamus. Several histamine-immunoreactive nerve fibers of this tract continued through the posterior commissure directly into the deep pineal gland. A few immunoreactive fibers were also observed in the habenular commissure. In midsagittal sections, histamine-immunoreactive nerve fibers were observed to enter the pineal stalk from the deep pineal gland. Most of histamine-immunoreactive fibers in the stalk continued towards the superficial pineal gland, but their number decreased in more distal locations of the stalk, indicating that some fibers terminate in the stalk as well. A few fibers were found to terminate in the most rostral part of the superficial pineal gland. The immunoreactive nerve fibers in the epithalamus and pineal complex were endowed with prominent varicosities. Taken together, these results indicate that histaminergic nerve fibers. originating from the posterior hypothalamus, project to the pineal complex of the rat. Histamine must therefore be considered a putative neurotransmitter contained in the central innervation of the pineal gland, but its function in pineal physiology has so far not been elucidated.
组胺作为神经调节剂。
影响因子：
13.9
作者：
Prell,GD;Green,JP
通讯作者：
Green,JP