Pulse-frequency-dependent resonance in a population of pyramidal neuron models
Pulse-frequency-dependent resonance in a population of pyramidal neuron models
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DOI：
10.1007/s00422-022-00925-w
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发表时间：
2022-03-18
影响因子：
1.9
通讯作者：
Durand，Dominique M.
中科院分区：
文献类型：
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作者：
Mori，Ryosuke;Mino，Hiroyuki;Durand，Dominique M.
随机共振是一种通过适当强度的加性随机噪声增强弱信号或阈下刺激的信息传输的现象。通过施加具有脉冲频率的确定性脉动电刺激（通常用于深部脑刺激（DBS））引起的另一种现象也显示出改善神经元模型中的信噪比。本研究的目的是测试的假设，即脉冲高频刺激可以提高检测的亚和阈上突触刺激的频率调谐的刺激在锥体神经元模型的人口。计算机模拟表明，从神经尖峰序列的人口估计的互信息显示了一个典型的共振曲线与峰值的脉冲频率在80-120 Hz，类似于用于DBS在临床情况下。它的结论是，“脉冲频率依赖性共振”（PFDR）可以增强信息传输的突触连接的网络在很大范围内。由于共振频率与临床使用的频率相匹配，PFDR可能有助于DBS的治疗作用机制。
Stochastic resonance is known as a phenomenon whereby information transmission of weak signal or subthreshold stimuli can be enhanced by additive random noise with a suitable intensity. Another phenomenon induced by applying deterministic pulsatile electric stimuli with a pulse frequency, commonly used for deep brain stimulation (DBS), was also shown to improve signal-to-noise ratio in neuron models. The objective of this study was to test the hypothesis that pulsatile high-frequency stimulation could improve the detection of both sub- and suprathreshold synaptic stimuli by tuning the frequency of the stimulation in a population of pyramidal neuron models. Computer simulations showed that mutual information estimated from a population of neural spike trains displayed a typical resonance curve with a peak value of the pulse frequency at 80–120 Hz, similar to those utilized for DBS in clinical situations. It is concluded that a “pulse-frequency-dependent resonance” (PFDR) can enhance information transmission over a broad range of synaptically connected networks. Since the resonance frequency matches that used clinically, PFDR could contribute to the mechanism of the therapeutic effect of DBS.