Endothelium-dependent relaxation in estrogen-treated spontaneously hypertensive rats.
Endothelium-dependent relaxation in estrogen-treated spontaneously hypertensive rats.
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雌激素治疗的自发性高血压大鼠的内皮依赖性松弛。
DOI：
10.1016/0014-2999(88)90231-2
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发表时间：
1988
影响因子：
5
通讯作者：
Mustafa,SJ
中科院分区：
文献类型：
--
作者：
Williams,SP;Shackelford,DP;Iams,SG;Mustafa,SJ
雌性自发性高血压大鼠（SHR）皮下注射美雌醇，每周两次，共12周。离体胸主动脉段，然后使用苯肾上腺素预收缩后，产生对乙酰胆碱或ATP的舒张反应曲线。雌激素治疗减轻了高血压的发展。此外，增强内皮依赖性舒张乙酰胆碱被视为雌激素治疗的SHR。然而，在ATP产生的松弛方面没有差异。由于乙酰胆碱和ATP的舒张都是内皮依赖性的，这些发现表明，乙酰胆碱和ATP产生的舒张可能涉及不同的机制。
Female spontaneously hypertensive rats (SHR) were injected subcutaneously with mestranol twice a week for 12 weeks. Isolated segments of thoracic aorta were then used to generate relaxation response curves to acetylcholine or ATP after precontraction with phenylephrine. Estrogen treatment attenuated the development of hypertension. Further, augmented endothelium-dependent relaxation to acetylcholine was seen in the estrogen-treated SHR. There was no difference, however, in the relaxation produced by ATP. Since the relaxation of both acetylcholine and ATP is endothelium-dependent, these findings suggest that different mechanisms may be involved in the relaxation produced by acetylcholine and ATP.