Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities
Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities
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DOI：
10.1111/j.1528-1167.2008.01680.x
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发表时间：
2008-11-01
期刊：
影响因子：
5.6
通讯作者：
Shields, W. Donald
中科院分区：
文献类型：
--
作者：
Caplan, Rochelle;Siddarth, Prabha;Shields, W. Donald
儿童失神癫痫（CAE）的精神，社会和职业成人结果差的证据表明长期未满足的心理健康，社会和职业需求。这项横断面研究探讨了行为/情感，认知和语言的共病，以及他们的相关性在儿童与CAE.69 CAE儿童年龄为9.6（SD = 2.49）岁和103年龄和性别匹配的正常儿童进行了半结构化的精神访谈，以及认知和语言测试。父母通过半结构化的精神病学访谈和儿童行为检查表（CBCL）提供了关于他们孩子的人口统计学，与行为相关的信息。与正常组相比，25%的CAE儿童有轻微的认知缺陷，43%的语言困难，61%的精神病诊断，特别是注意缺陷多动障碍（ADHD）和焦虑症，和30%的临床相关CBCL宽带评分。在临床/临界范围内最常见的CBCL窄带因子评分是注意力和躯体主诉，其次是社会和思想问题。病程、癫痫发作频率和抗癫痫药物（AED）治疗与认知、语言和精神共病的严重程度相关。只有23%的CAE受试者对这些问题进行了干预。行为、情感、认知和语言受损的高比率和低干预率应提醒临床医生需要早期识别和治疗CAE儿童，特别是那些病程较长、癫痫发作不受控制和AED治疗的儿童。
Evidence for a poor psychiatric, social, and vocational adult outcome in childhood absence epilepsy (CAE) suggests long-term unmet mental health, social, and vocational needs. This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in children with CAE.Sixty-nine CAE children aged 9.6 (SD = 2.49) years and 103 age- and gender-matched normal children had semistructured psychiatric interviews, as well as cognitive and linguistic testing. Parents provided demographic, seizure-related, and behavioral information on their children through a semi-structured psychiatric interview and the child behavior checklist (CBCL).Compared to the normal group, 25% of the CAE children had subtle cognitive deficits, 43% linguistic difficulties, 61% a psychiatric diagnosis, particularly attention deficit hyperactivity disorder (ADHD) and anxiety disorders, and 30% clinically relevant CBCL broad band scores. The most frequent CBCL narrow band factor scores in the clinical/borderline range were attention and somatic complaints, followed by social and thought problems. Duration of illness, seizure frequency, and antiepileptic drug (AED) treatment were related to the severity of the cognitive, linguistic, and psychiatric comorbidities. Only 23% of the CAE subjects had intervention for these problems.The high rate of impaired behavior, emotions, cognition, and language and low intervention rate should alert clinicians to the need for early identification and treatment of children with CAE, particularly those with longer duration of illness, uncontrolled seizures, and AED treatment.