Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
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DOI：
10.1038/nrm.2016.62
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Kajimura S
中科院分区：
文献类型：
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作者：
Inagaki T;Sakai J;Kajimura S
白色脂肪细胞以甘油三酯的形式储存多余的能量，而棕色和米色脂肪细胞以热量的形式耗散能量。这种产热功能依赖于棕色和米色脂肪细胞特异性基因程序的激活，这些基因程序由脂肪选择性染色质结构和一组独特的转录和表观遗传调节因子协调调节。许多转录和表观遗传调节因子也需要促进米色脂肪细胞的生物合成，以响应各种环境刺激。更好地了解棕色和米色脂肪细胞的产生和功能的分子机制是必要的，使我们能够控制脂肪细胞的命运和刺激产热。这可能为治疗肥胖症和肥胖相关疾病（如2型糖尿病）提供治疗方法。
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige adipocytes dissipate energy in the form of heat. This thermogenic function relies on the activation of brown and beige adipocyte-specific gene programmes that are coordinately regulated by adipose-selective chromatin architectures and by a set of unique transcriptional and epigenetic regulators. A number of transcriptional and epigenetic regulators are also required for promoting beige adipocyte biogenesis in response to various environmental stimuli. A better understanding of the molecular mechanisms governing the generation and function of brown and beige adipocytes is necessary to allow us to control adipose cell fate and stimulate thermogenesis. This may provide a therapeutic approach for the treatment of obesity and obesity-associated diseases, such as type 2 diabetes.