Localization of leptin receptor mRNA expression in mouse brain
Localization of leptin receptor mRNA expression in mouse brain
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DOI：
10.1097/00001756-199611040-00045
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发表时间：
1996-11-04
期刊：
影响因子：
1.7
通讯作者：
Storlien, L
中科院分区：
文献类型：
--
作者：
Huang, XF;Koutcherov, I;Storlien, L
用非放射性原位杂交方法研究了瘦素受体在C57小鼠脑中的分布。瘦素受体mRNA的表达最高的弓状核和正中隆起的下丘脑，但它也丰富的海马，主要是在齿状回和CA1，并检测到在梨状皮质和内侧缰核的内侧缘低水平。本研究中含瘦素受体的神经元的定位表明瘦素受体可能在含神经肽Y的神经元上表达。
THE distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in the dentate gyrus and CA1, and was detected at low levels in piriform cortex and the medial margin of the medial habenular nucleus. The localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptor is expressed on neuropeptide Y-containing neurones.