Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signalling.
Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signalling.
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稳住船：膜和核类固醇受体信号传导的整合机制。
DOI：
10.1038/sj.embor.7400336
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发表时间：
2005
期刊：
影响因子：
7.7
通讯作者：
Lange,CarolA
中科院分区：
文献类型：
--
作者：
Watson,CherylS;Lange,CarolA
这次统一的会议提供了新的见解之间的连接膜和核细胞的类固醇激素受体（孕激素，雌激素，雄激素，盐皮质激素和糖皮质激素）的主要类别的行动，和其他重要成员的核受体超家族（受体甲状腺激素（TH）和维生素D）。在会议上发言者解决了有关类固醇膜受体的特性和行动的重要问题，其中许多仍然没有解决。主题范围从性类固醇在卵巢反应性癌症中的细胞生物学到类固醇受体（SR）信号在非经典作用部位的新方面。在这里，我们提出了会议的亮点，解决了关于膜和核受体启动信号的整合的“紧迫问题”。我们主要集中在新的信息膜SR的特点，他们的关系，他们的核同行和新的实验方法来解决这些问题。
This unifying conference provided new insights into the connections between the membrane and nuclear cellular actions of the main classes of steroid hormone receptors (progesterone, oestrogen, androgen, mineralocorticoid and glucocorticoid), and other important members of the nuclear receptor superfamily (receptors for thyroid hormone (TH) and vitamin D). Speakers at the conference addressed important questions about the characteristics and actions of steroid membrane receptors, many of which remain unresolved. The topics ranged from the cell biology of sex steroids in hormonally responsive cancers to new aspects of steroid receptor (SR) signalling at non-classical sites of action. Here, we present highlights from the meeting that address ‘burning questions’ about the integration of membrane-and nuclearreceptor-initiated signalling. We concentrate primarily on new information about the characteristics of membrane SRs, their relationship to their nuclear counterparts and new experimental approaches for addressing these issues.