Unique organization of the frontonasal ectodermal zone in birds and mammals
Unique organization of the frontonasal ectodermal zone in birds and mammals
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DOI：
10.1016/j.ydbio.2008.10.026
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Marcucio, Ralph S.
中科院分区：
文献类型：
--
作者：
Hu, Diane;Marcucio, Ralph S.
鸟类和哺乳动物的面部表现出显着的形态多样性，但如何产生变化还没有得到很好的理解。我们以前已经证明，面部外胚层，我们命名的区域，额鼻外胚层区（FEZ），调节近远侧延伸和背腹极性的上颌骨在鸟类。在这项工作中，我们检查了小鼠胚胎中的等效外胚层，并确定FEZ在小鼠中是保守的。然而，我们的研究结果表明，在小鼠和小鸡的FEZ的组织和成分的根本差异可能是不同的生长特征，区分哺乳动物和鸟类胚胎在发育的最早阶段。最后，目前的模型表明，神经嵴细胞调节上颌的大小和形状，鸟类神经嵴内的骨形态发生蛋白（BMPs）的信号传导有助于指导这一过程。在这里，我们表明，神经嵴细胞中的BMP表达模式的调节部分由FEZ的信号。我们的工作结果调和了一个保守的信号中心，发展中国家的脸的模式增长可能会产生不同动物之间的形态多样性。FEZ中基因表达模式组织的微妙变化可能是物种之间和物种内观察到的形态变异的基础，在极端情况下，变异可能产生疾病表型。(C)2008年爱思唯尔公司All rights reserved.
The faces of birds and mammals exhibit remarkable morphologic diversity, but how variation arises is not well-understood. We have previously demonstrated that a region of facial ectoderm which we named the, frontonasal ectodermal zone (FEZ), regulates proximo-distal extension and dorso-ventral polarity of the upper jaw in birds. In this work, we examined the equivalent ectoderm in murine embryos and determined that the FEZ is conserved in mice. However, our results revealed that fundamental differences in the organization and constituents of the FEZ in mice and chicks may underlie the distinct growth characteristics that distinguish mammalian and avian embryos during the earliest stages of development. Finally, current models suggest that neural crest cells regulate size and shape of the upper jaw, and that signaling by Bone morphogenetic proteins (Bmps) within avian neural crest helps direct this process. Here we show that Bmp expression patterns in neural crest cells are regulated in part by signals from the FEZ. The results of our work reconcile how a conserved signaling center that patterns growth of developing face may generate morphologic diversity among different animals. Subtle changes in the organization of gene expression patterns in the FEZ could underlie morphologic variation observed among and within species, and at extremes, variation could produce disease phenotypes. (C) 2008 Elsevier Inc. All rights reserved.