One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids.
One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids.
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DOI：
10.3390/molecules15107423
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发表时间：
2010-10-22
期刊：
影响因子：
--
通讯作者：
Mphahlele MM
中科院分区：
文献类型：
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作者：
Mphahlele MJ;Mphahlele MM
在三环己基膦存在下，钯催化2-芳基-4-氯-3-碘喹啉与过量芳基硼酸（2.5等量）的铃木交联，在一锅操作中得到2,3,4-三芳基喹啉。初步制备了2,3-二芳基-4-氯喹啉，并转化为4-氨基-2,3-二芳基喹啉和2,3-二芳基喹啉-4(1H)-喹啉。
Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.