Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice
Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice
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DOI：
10.1016/j.bbr.2006.07.029
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发表时间：
2006-11-25
影响因子：
2.7
通讯作者：
Crusio, Wim E.
中科院分区：
文献类型：
--
作者：
Mineur, Yann S.;Belzung, Catherine;Crusio, Wim E.
被广泛接受的抑郁症的素质 - 应激假说假定遗传因素导致了生物易感性。基于这一概念，不可预测的慢性轻度应激（UCMS）动物模型得以建立。抗抑郁药物可以逆转UCMS的大多数效应，这表明其具有很强的预测效度。在啮齿动物中，UCMS也具有良好的表面效度，因为它能引发类似抑郁的症状。虽然关于大鼠的研究很丰富，但关于小鼠的UCMS文献相对有限。报告有时相互矛盾，这使得很难明确小鼠中应激诱导的类似抑郁行为的特征。由于不同的研究小组在实验中经常使用不同的品系，对UCMS的不同品系易感性可能至少部分解释了这些差异。此外，测试方法的差异增加了另一层复杂性。关于遗传因素的作用以及它们与环境在应激诱导的与抑郁症相关的行为变化发展中的相互作用，我们知之甚少，尽管最近的研究明确表明了特定基因多态性对应激诱导的抑郁症状的影响，以及应激对基因表达的影响。在本研究中，我们研究了UCMS对一系列不同测试的影响，这些测试用于测量三种在行为和遗传上不同的近交系小鼠的焦虑和类似抑郁的行为。这些实验的目的是在UCMS处理后获得遗传/表型差异较大的小鼠品系更清晰的行为特征，并评估UCMS模型在小鼠中的局限性和优势。（c）2006爱思唯尔公司。保留所有权利。
The widely accepted stress-diathesis hypothesis of depression postulates that genetic factors contribute to biological vulnerability. Based on this concept, the unpredictable chronic mild stress (UCMS) animal model was developed. Most effects of UCMS can be reversed by antidepressant agents, illustrating a strong predictive validity. In rodents, UCMS also has good face validity as it can elicit depression-like symptoms. While abundant for rats, the UCMS literature on mice is relatively limited. Reports sometimes are contradictory, making it difficult to establish a clear profile of stress-induced depression-like behaviors in mice. As different groups often use different strains for their experiments, differential strain susceptibility to UCMS may provide at least a partial explanation of these discrepancies. Moreover, differences in testing methodology add another level of complexity. Very little is known about the role of genetic factors and their interactions with the environment in the development of stress-induced behavioral changes relevant to depression, though recent studies unequivocally demonstrated the effects of specific gene polymorphisms on stress-induced depressive symptoms, as well as the effects of stress on gene expression. In the present study, we investigated the effects of UCMS on a battery of different tests measuring anxiety and depression-like behaviors in three behaviorally and genetically distinct inbred strains. The goals of these experiments are to obtain a clearer behavioral profile of genetically/phenotypically distant mouse strains after UCMS treatment and to evaluate the limitations and strengths of the UCMS model in mice. (c) 2006 Elsevier B.V. All rights reserved.