Hemostasis abnormalities in liver cirrhosis: myth or reality?
Hemostasis abnormalities in liver cirrhosis: myth or reality?
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DOI：
10.20452/pamw.448
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发表时间：
2008-07
期刊：
影响因子：
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通讯作者：
A. Tripodi
中科院分区：
文献类型：
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作者：
A. Tripodi
慢性肝病的特点是全局性止血缺陷，包括血小板-血管壁相互作用（原发性止血）、纤维蛋白溶解和凝血导致相关实验室检查异常。异常检查与出血之间的因果关系已被广泛接受，尽管事实上异常检查与出血的关系很差。最近来自文献的证据对上述范式提出了质疑，并为该领域的实验室和临床研究开辟了新的方向。
Chronic liver disease is characterized by a global hemostatic defect that includes platelet-vessel wall interaction (primary hemostasis), fibrinolysis and coagulation causing abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with bleeding. Recent evidence from the literature disputes the above paradigm and open new directions for laboratory and clinical research in this field.