Functional properties of the surface of the vermilion border of the lips are distinct from those of the facial skin
Functional properties of the surface of the vermilion border of the lips are distinct from those of the facial skin
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DOI：
10.1046/j.1365-2133.2003.05741.x
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发表时间：
2004-03-01
影响因子：
10.3
通讯作者：
Tagami, H
中科院分区：
文献类型：
--
作者：
Kobayashi, H;Tagami, H
背景唇的朱红缘（简称唇）是面部口腔粘膜持续暴露于外部的唯一部位。尽管其突出的存在于脸上，构成不仅是化妆品的目标，但也为各种皮肤病的网站，其功能特性仍然几乎unknow.Objectives阐明的功能特性的朱红边界的lips.Methods我们研究了嘴唇的生物物理特性，通过比较他们与303名健康的日本女性，年龄在21-80岁，在冬季的脸颊皮肤。我们使用了一个封闭的腔室系统来测量嘴唇的经上皮水分损失（TEWL），以避免呼吸的影响。此外，我们研究的影响，口服etretinate，一种药物，肯定会产生干燥，鳞状的嘴唇，7名男性患者年龄在49-89（平均67）years.Results的嘴唇上TEWL显着几乎三倍高的嘴唇上的脸颊，这是一个网站，显示远远高于其他身体领域。TEWL随年龄增长而下降，唇部较颊部明显。高频电导，表面水合状态的参数，是显着低于嘴唇上的脸颊。获得的平均值约为脸颊的三分之一，在嘴唇或脸颊上均未观察到与年龄相关的变化。唇部表皮细胞角化不全，比颊部大。此外，我们检测到一个显着增加TEWL的嘴唇，以及在脸颊上的患者治疗与口服etretinate.Conclusions它似乎是不完整的角质形成的嘴唇表面是负责差的屏障功能和持水能力。
Background The vermilion border of the lips (lip for short) is the only part on the face where the oral mucosa is persistently exposed to the outside. Despite its prominent presence on the face, constituting not only the target of cosmetics but also the site for various skin diseases, its functional properties remain almost unknown.Objectives To elucidate the functional properties of the vermilion border of the lips.Methods We studied the biophysical properties of the lip by comparing them with those of the cheek skin in 303 healthy Japanese females aged 21-80 years, in winter. We used a closed-chamber system to measure transepithelial water loss (TEWL) of the lip to avoid the effect of breathing. Moreover, we examined the effects of oral etretinate, a drug that definitely produces dry, scaly lips, on the lips of seven male patients aged 49-89 (average 67) years.Results TEWL was significantly almost three times as high on the lips as that on the cheek which is a site that shows far higher levels than do other body areas. TEWL decreased with age more remarkably on the lip than on the cheek. High-frequency conductance, a parameter for surface hydration state, was significantly lower on the lip than on the cheek. The mean values obtained were about one-third of those on the cheek, and no age-related changes were observed either on the lip or on the cheek. The superficial epithelial cells on the lip were parakeratotic and larger than those of the cheek skin. Furthermore, we detected a significant increase in TEWL on the lip as well as on the cheek of patients treated with oral etretinate.Conclusions It appears that the incomplete corneocyte formation of the lip surface is responsible for the poor barrier function and water-holding capacity.