The Childhood Cancer Survivor Study: A National Cancer Institute-Supported Resource for Outcome and Intervention Research
The Childhood Cancer Survivor Study: A National Cancer Institute-Supported Resource for Outcome and Intervention Research
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DOI：
10.1200/jco.2009.22.3339
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发表时间：
2009-05-10
影响因子：
45.3
通讯作者：
Zeltzer, Lonnie K.
中科院分区：
文献类型：
--
作者：
Robison, Leslie L.;Armstrong, Gregory T.;Zeltzer, Lonnie K.
过去 40 年来，儿童癌症的生存率急剧上升，目前 5 年生存率已接近 80%。对于许多诊断组来说，随着多模式方法（通常包括联合化疗加或不加放疗）的广泛采用，生存率从 20 世纪 70 年代开始迅速提高。随着生存率的提高，人们认识到幸存者面临健康和生活质量不良结果的风险，该风险受到宿主、疾病和治疗相关因素的影响。 1994 年，美国国家癌症研究所资助了儿童癌症幸存者研究，这是一项多机构研究计划，旨在建立一个由 14,000 多名 1970 年至 1986 年间诊断的儿童和青少年癌症 5 年幸存者组成的大型且具有广泛特征的队列。这项正在进行的研究反映了迄今为止收集到的有关儿童和青少年癌症幸存者的最全面的信息，为调查有关儿童癌症幸存者的当前和未来问题提供了一个动态框架和资源。
Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors.