Chemokine CXCL12 and its receptors in the developing central nervous system: Emerging themes and future perspectives
Chemokine CXCL12 and its receptors in the developing central nervous system: Emerging themes and future perspectives
复制标题
DOI：
10.1002/dneu.22041
复制
发表时间：
2012-10
影响因子：
3
通讯作者：
Yan Zhu;F. Murakami
中科院分区：
文献类型：
--
作者：
Yan Zhu;F. Murakami
稳态趋化因子CXCL12（也称为SDF-1）及其受体CXCR4对于神经系统的正常发育是不可或缺的。这种趋化因子系统在许多神经发育过程中发挥着多种功能，从这些过程中，潜在的分子和细胞机制开始被阐明。最近将 CXCR7 鉴定为 CXCL12 的第二种受体，为深入了解 CXCL12 在神经系统中的运作方式提供了机会。在这里，我们回顾了 CXCL12 在中枢神经系统发育中的不同作用，总结了揭示 CXCR7 功能的最新进展，并讨论了这些工作中出现的共同主题和未来的前景。 © 2012 Wiley periodicals, Inc. 开发 Neurobiol，2012
Homeostatic chemokine CXCL12 (also known as SDF‐1) and its receptor CXCR4 are indispensable for the normal development of the nervous system. This chemokine system plays a plethora of functions in numerous neural developmental processes, from which the underlying molecular and cellular mechanisms are beginning to be unravelled. Recent identification of CXCR7 as a second receptor for CXCL12 provides opportunities to gain deeper insights into how CXCL12 operates in the nervous system. Here, we review the diverse roles of CXCL12 in the developing central nervous system, summarize the recent progress in uncovering CXCR7 functions, and discuss the emerging common themes from these works and future perspectives. © 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012