"LONG COVID": an insight
"LONG COVID": an insight
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DOI：
10.26355/eurrev_202109_26669
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发表时间：
2021-01-01
影响因子：
3.3
通讯作者：
Almutairi, S. B.
中科院分区：
文献类型：
--
作者：
Ahmad, M. S.;Shaik, R. A.;Almutairi, S. B.
我们进行这次系统综述的目的是分析和回顾目前已发表的与长期新冠病毒相关的文献，了解其模式，并预测对幸存者的长期影响。截至 2021 年 5 月，我们在数据库中彻底搜索了相关文章。符合我们纳入和排除标准的研究文章由两名独立研究人员进行了评估和审查。通过标题和摘要对确定的文章进行初步筛选，最终选出249篇。因此，根据我们的纳入标准对 167 篇全文文章进行了评估和审查，因此 20 篇文章被认为符合条件并在本分析中进行了分析。所有研究均包括 18 岁至 60 岁以上的成年人口。 COVID-19患者在急性感染阶段的中位住院时间为8天至17天。几乎所有研究中，COVID-19 患者最常见的长期症状包括持续疲劳和呼吸困难。其他报告的常见症状包括：气短、咳嗽、关节痛、胸痛或胸闷、头痛、嗅觉/味觉丧失、喉咙痛、腹泻、记忆力丧失、抑郁、焦虑。相关心血管事件包括心律失常、心悸和低血压、心率增加、静脉血栓栓塞性疾病、心肌炎和急性/失代偿性心力衰竭。在神经系统表现中，最常见的是头痛、周围神经病变症状、记忆问题、注意力集中和睡眠障碍，且出现频率各不相同。影响心理能力的心理健康问题、情绪波动（即焦虑和抑郁）以及睡眠障碍很常见。此外，腹泻、呕吐、消化功能紊乱以及食欲不振或体重减轻是常见的胃肠道表现。因此，对于长期的新冠肺炎病例需要进行适当的临床评估，这反过来可能有助于我们识别风险因素和病因，并且在我的帮助下，我们可以尽早采用适当的管理策略进行治疗。
We aimed this systematic review to analyze and review the currently available published literature related to long COVID, understanding its pattern, and predicting the long-term effects on survivors. We thoroughly searched the databases for relevant articles till May 2021. The research articles that met our inclusion and exclusion criteria were assessed and reviewed by two independent researchers. After preliminary screening of the identified articles through title and abstract, 249 were selected. Consequently, 167 full-text articles were assessed and reviewed based on our inclusion criteria and thus 20 articles were regarded as eligible and analyzed in the present analysis. All the studies included adult population aged between 18 and above 60 years. The median length of hospital stay of the COVID-19 patients during the acute infection phase ranged from 8 days to 17 days. The most common prevalent long-term symptoms in COVID-19 patients included persistent fatigue and dyspnea in almost all of the studies. Other reported common symptoms included: shortness of breath, cough, joint pain, chest pain or tightness, headache, loss of smell/taste, sore throat, diarrhea, loss of memory, depression, anxiety. Associated cardiovascular events included arrhythmias, palpitations and hypotension, increased HR, venous thromboembolic diseases, myocarditis, and acute/decompensated heart failure as well. Among neurological manifestations headache, peripheral neuropathy symptoms, memory issues, concentration, and sleep disorders were most commonly observed with varying frequencies. Mental health issues affecting mental abilities, mood fluctuations namely anxiety and depression, and sleep disorders were commonly seen. Further, diarrhea, vomiting, digestive disorders, and Loss of appetite or weight loss are common gastrointestinal manifestations. Therefore, appropriate clinical evaluation is required in long COVID cases which in turn may help us to identify the risk factors, etiology, and to my help, we treat them early with appropriate management strategies.