Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteremia.
Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteremia.
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急性白血病口服甲氧苄啶-磺胺甲恶唑预防失败：从引起菌血症的肠杆菌科菌株中分离耐药质粒。
DOI：
10.1056/nejm198201073060105
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Guiney,DG
中科院分区：
文献类型：
--
作者：
Wilson,JM;Guiney,DG
最近对粒细胞减少症患者的几项研究表明，口服甲氧苄啶-磺胺甲恶唑（TMP-SMX）预防性给药可有效预防肠杆菌科败血症。12345然而，我们最近发现2例急性白血病和粒细胞减少症患者接受了口服TMP-SMX预防性给药，但随后发生了对TMP-SMX耐药的肠杆菌科败血症。在一名患者中，从两种不同的细菌物种中分离出编码对甲氧苄啶和磺胺的抗性的可转移质粒。在另一个病人，一个可转移的磺胺类药物耐药质粒被发现在一个单一的strain.MethodsPatients和细菌strainsThe TMP-SMX耐药菌株染色体介导的甲氧苄啶耐药一起。
Several recent studies of patients with granulocytopenia have shown that the prophylactic administration of oral trimethoprim–sulfamethoxazole (TMP-SMX) is effective in preventing sepsis with Enterobacteriaceae.12345However, we have recently seen two patients with acute leukemia and granulocytopenia who received oral TMP-SMX prophylaxis but subsequently had sepsis with Enterobacteriaceae that were resistant to TMP-SMX. In one patient, a transferable plasmid encoding resistance to trimethoprim and sulfonamide was isolated from two different bacterial species. In the other patient, a transferable sulfonamide-resistance plasmid was found together with chromosomally mediated trimethoprim resistance in a single strain.MethodsPatients and Bacterial StrainsThe TMP-SMX-resistant strains were . . .