Influence of albumin on the extravascular distribution of unconjugated bilirubin.
Influence of albumin on the extravascular distribution of unconjugated bilirubin.
复制标题
白蛋白对未结合胆红素血管外分布的影响。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
Nathaniel I. Berlin
中科院分区：
文献类型：
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作者：
Joseph R. Bloomer;Paul D. Berk;J. Vergalla;Nathaniel I. Berlin
摘要1. [3 H]胆红素和1311-标记白蛋白同时给予6名健康成人静脉途径，并测量血浆中的量数天。数据的多房室分析表明，[3 H]胆红素从血浆进入肝外血管外空间的速率为29.7 f.血浆池的7.3%（平均k SEM）/h，而1311标记的白蛋白从血浆进入血管外空间的速率仅为血浆池的7.2%/h。2.发现胆红素在静脉内给药24小时内在患有Crigler-Najjar综合征的儿童的全身达到平衡，而13 ′ I标记的白蛋白在人类受试者中需要4-5天。3. 6名健康成人血浆数据的多房室分析表明，肝外血管外间隙中的物质质量相对于血浆中的物质质量，非结合胆红素大于白蛋白。4.纯合古恩大鼠中非结合胆红素的组织分布研究表明，组成快速交换的血管外白蛋白池（肝脏、肾脏和肠）的器官中蓄积的非结合胆红素超过其白蛋白含量，而组成缓慢交换的血管外白蛋白池（肌肉、脂肪和皮肤）的组织中蓄积的非结合胆红素较少。5.这些结果表明，非结合胆红素在血浆和肝外血管外部位之间的移动速度比与白蛋白结合的转运速度更快。它们还表明，非结合胆红素的血管外结合包括组织部位以及血管外白蛋白。
SUMMARY 1. [3H]Bilirubin and 1311-labelled albumin were given simultaneously to six healthy adults by intravenous route and the amounts in the plasma were measured for several days. Multicompartmental analysis of the data showed that the rate of movement of [3H]bilirubin from the plasma into the extrahepatic extravascular space was 29.7 f. 7.3% (mean k SEM) of the plasma pool/h, whereas the rate of movement of 1311-labelled albumin from plasma into the extravascular space was only 7.2f 1.0% of the plasma pool/h. 2. ['4C]Bilirubin was found to equilibrate throughout the body of a child with the Crigler-Najjar syndrome within 24 h of intravenous administration, whereas l3 'Ilabelled albumin required 4-5 days in human subjects. 3. Multicompartmental analysis of the plasma data in the six healthy adults indicated that the mass of material in the extrahepatic extravascular space relative to that in plasma was greater for unconjugated bilirubin than for albumin. 4. Studies of the tissue distribution of unconjugated bilirubin in homozygous Gunn rats demonstrated that the organs which comprise the rapidly exchanging extravascular albumin pool (liver, kidney and intestine) accumulated unconjugated bilirubin in excess of their albumin content, whereas lesser amounts of unconjugated bilirubin were accumulated in the tissues which make up the slowly exchanging extravascular albumin pool (muscle, fat and skin). 5. These findings indicate that unconjugated bilirubin moves more rapidly between plasma and extrahepatic extravascular sites than can be accounted for by transport bound to albumin. They also indicate that extravascular binding of unconjugated bilirubin includes tissue sites, as well as extravascular albumin.