Ethanol-induced suppression of cell-mediated immunity in the mouse.
Ethanol-induced suppression of cell-mediated immunity in the mouse.
复制标题
乙醇诱导的小鼠细胞介导的免疫抑制。
DOI：
10.1111/j.1530-0277.1992.tb01386.x
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Andrea K. Hubbard
中科院分区：
文献类型：
--
作者：
Ruani Jayasinghe;Gerald Gianutsos;Andrea K. Hubbard
Among its many effects on multiple organ systems, ethanol abuse also elicits potent immunomodulatory effects as well. Increased susceptibility to disease as well as increased severity in infection is well documented in alcoholics and may be related to an altered immune response. A mouse model has been developed in which C57Bl/6 mice are fed a nutritionally adequate liquid diet in which ethanol provides 27% of total calories (3.75% ethanol) in order to examine the effects of short-term, low dose ethanol administration on cell mediated immunity. All mice were evaluated for percentage of plasma ethanol, impaired motor skills and impaired delayed type hypersensitivity to sheep erythrocytes. Animals fed the ethanol diet for 5, 10, or 15 days evidenced plasma ethanol concentrations between 0.13% and 0.23% as well as significantly impaired motor skills. Mice maintained on the ethanol diet 8 days prior to erythrocyte sensitization and on the 6 days between sensitization and challenge demonstrated a significant reduction of 58% in footpad swelling. Moreover, mice fed ethanol for only the 6 days between erythrocyte sensitization and challenge also demonstrated a significant decrease of 35% in this delayed type immune response. However, animals administered ethanol prior to sensitization and then switched to control diet between sensitization and challenge evidenced a normal cell-mediated immune response to the sheep erythrocytes. Thus, it appears that the critical time of low dose ethanol-induced immunosuppression is between immunogen sensitization and challenge.
乙醇介导的免疫抑制的新机制。
影响因子：
4.3
作者：
Kaplan,DR
通讯作者：
Kaplan,DR
用含乙醇饮食处理的大鼠 T 细胞对白细胞介素 2 利用率的改变。
DOI：
10.1111/j.1530-0277.1990.tb00480.x
发表时间：
1990
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Jerrells,TR;Perritt,D;Eckardt,MJ;Marietta,C
通讯作者：
Marietta,C
乙醇在细胞免疫系统中引起的功能和数值改变。
DOI：
10.1016/0162-3109(88)90055-0
发表时间：
1988
期刊：
Immunopharmacology
影响因子：
--
作者：
Mufti,SI;Prabhala,R;Moriguchi,S;Sipes,IG;Watson,RR
通讯作者：
Watson,RR