Developing an Interface and Investigating Optimal Parameters for Real-Time Intracardiac Subharmonic-Aided Pressure Estimation.
Developing an Interface and Investigating Optimal Parameters for Real-Time Intracardiac Subharmonic-Aided Pressure Estimation.
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DOI：
10.1109/tuffc.2020.3016264
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Dave JK
中科院分区：
文献类型：
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作者：
Esposito C;Dickie K;Forsberg F;Dave JK
本研究的重点是确定定制界面的实时功能，并利用Definity Lantheus Medical Imaging Inc)和Sonazoid （GE Healthcare）微泡研究心脏内亚谐波辅助压力估计（SHAPE）的最佳参数。心脏腔内的压力测量为管理心血管疾病提供了关键信息。目前有创的临床心导管插入术的另一种选择是利用超声造影剂和SHAPE来无创地估计心内压力。因此，本工作开发了一个定制界面（在SonixTablet， BK Ultrasound上）用于实时心脏内SHAPE。体外应用多普勒血流模体模拟心脏内的动态压力变化。使用Definity （15.0 ~ 22.5 μL微球，对应0.1 ~ 0.15 mL）和Sonazoid （GE Healthcare, 0.4 ~ 1.2 μL微球，对应0.05 ~ 0.15 mL）微泡。在不同的发射频率（2.5-4.0 MHz）和脉冲整形选项（方波和啁啾下降）下获取数据，以确定最佳发射参数。同时获得的射频数据与环境压力数据进行了比较。对于Definity， 3.0 MHz的啁啾下降脉冲在SHAPE和压力导管数据之间产生了最高的相关性（r = - 0.77±0.2）。对于Sonazoid， 2.5 MHz的方波脉冲产生了最高的相关性（r = - 0.72±0.2）。总之，定制界面的实时功能得到了验证，并确定了使用Definity和Sonazoid进行心脏内SHAPE的最佳参数。
This study focuses on determining the real-time functionality of a customized interface and investigating the optimal parameters for intra-cardiac subharmonic aided pressure estimation (SHAPE) utilizing Definity Lantheus Medical Imaging Inc) and Sonazoid (GE Healthcare) microbubbles. Pressure measurements within the chambers of the heart yield critical information for managing cardiovascular diseases. An alternative to current, invasive, clinical cardiac catheterization procedures is utilizing ultrasound contrast agents and SHAPE to noninvasively estimate intra-cardiac pressures. Therefore, this work developed a customized interface (on a SonixTablet, BK Ultrasound) for real-time intra-cardiac SHAPE. In vitro, a Doppler flow phantom was utilized to mimic the dynamic pressure changes within the heart. Definity (15.0 to 22.5 μL microspheres; corresponding to 0.1 to 0.15 mL) and Sonazoid (GE Healthcare; 0.4 to 1.2 μL microspheres; corresponding to 0.05 to 0.15 mL) microbubbles were used. Data was acquired for varying transmit frequencies (2.5–4.0 MHz), and pulse shaping options (square wave and chirp down) to determine optimal transmit parameters. Simultaneously obtained radiofrequency data and ambient pressure data were compared. For Definity, the chirp down pulse at 3.0 MHz yielded the highest correlation (r = −0.77 ± 0.2) between SHAPE and pressure catheter data. For Sonazoid, the square wave pulse at 2.5 MHz yielded the highest correlation (r = −0.72 ± 0.2). In conclusion, the real-time functionality of the customized interface has been verified and the optimal parameters for utilizing Definity and Sonazoid for intra-cardiac SHAPE have been determined.