Incidence patterns of soft tissue sarcomas, regardless of primary site, in the Surveillance, Epidemiology and End Results program, 1978-2001: an analysis of 26,758 cases
Incidence patterns of soft tissue sarcomas, regardless of primary site, in the Surveillance, Epidemiology and End Results program, 1978-2001: an analysis of 26,758 cases
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DOI：
10.1002/ijc.22239
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发表时间：
2006-12-15
影响因子：
6.4
通讯作者：
Devesa, Susan S.
中科院分区：
文献类型：
--
作者：
Toro, Jorge R.;Travis, Lois B.;Devesa, Susan S.
软组织肉瘤（STS）是一组不常见的异质性肿瘤，表现出广泛的分化，可能反映病因的区别。STS的常规表格不具有形态学特异性。此外，在大多数标准评估中，没有将所有器官中出现的肉瘤包括在内，这低估了真实的比率。我们分析了1978-2001年STS的监测、流行病学和最终结果项目的发病率，不考虑原发部位，骨和关节除外，使用2002年WHO分类标准。共有26，758例病例可供分析。平滑肌瘤占23.9%，恶性纤维组织细胞瘤占17.1%，脂肪肉瘤占11.5%，皮肤纤维肉瘤占10.5%，横纹肌肉瘤占4.6%，血管瘤占4.1%。近一半（47.9%）的肉瘤发生在软组织，14.0%发生在皮肤，7.0%发生在子宫。总体而言，黑人妇女的发病率最高（6.26/100 000妇女年），白色妇女的发病率最低（4.60/100 000）。白色男性和女性中，经性别因素调整的发病率分别以每年1.2%和0.8%的速度增长，这两种趋势都具有统计学意义，而黑人的发病率略有下降。大约40%的女性平滑肌瘤起源于子宫，黑人/白色比例为1.7。当我们考虑到与白色妇女相比，黑人妇女子宫完整的患病率较低时，这一比率增加到2.0。总的STS率随着年龄的增长呈指数级上升。子宫平滑肌肉瘤和皮肤纤维肉瘤的发病率在生育期迅速增加，分别在40岁和50岁左右达到高峰。STS的发病模式因组织学类型而异，支持这些肿瘤可能在病因学上不同的观点。(c)2006威利-利斯公司
Soft tissue sarcomas (STS) are a heterogeneous group of uncommon tumors that show a broad range of differentiation that may reflect etiologic distinction. Routine tabulations of STS are not morphology-specific. Further, the lack of inclusion of sarcomas arising in all organs in most standard evaluations underestimates the true rates. We analyzed the 1978-2001 Surveillance, Epidemiology and End Results program incidence rates of STS regardless of primary site, except bones and joints, using the 2002 criteria of the WHO classification. There were 26,758 cases available for analysis. Leiomyosarcomas accounted for 23.9%, malignant fibrous histiocytomas 17.1%, liposarcomas 11.5%, dermatofibrosarcomas 10.5%, rhabdomyosarcomas 4.6% and angiosarcomas 4.1%. Almost half (47.9%) of the sarcomas arose in the soft tissues, 14.0% in the skin and 7.0% in the uterus. Overall, incidence rates were highest among black women (6.26/100,000 woman years) and the lowest among white women (4.60/100,000). Age-adjusted rates increased at 1.2% and 0.8% per year among white males and females, respectively, both trends statistically significant, while rates among blacks declined slightly. About 40% of leiomyosarcomas among women were uterine in origin, with a black/white rate ratio of 1.7. This rate ratio increased to 2.0 when we accounted for the lower prevalence of intact uteri among black compared to white women. Total STS rates rose exponentially with age. Rates for both uterine leiomyosarcoma and dermatofibrosarcoma increased rapidly during the childbearing years, peaking at about age 40 and 50, respectively. Incidence patterns of STS varied markedly by histologic type, supporting the notion that these tumors may be etiologically distinct. (c) 2006 Wiley-Liss, Inc.