Notch signaling as a novel regulator of metabolism.
Notch signaling as a novel regulator of metabolism.
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DOI：
10.1016/j.tem.2015.02.006
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Kuang S
中科院分区：
文献类型：
--
作者：
Bi P;Kuang S
人类在进化上没有为现代高热量饮食和久坐的生活方式做好准备，现在前所未有地容易患上代谢紊乱，如肥胖症、2型糖尿病、非酒精性脂肪肝和心血管疾病。这些代谢状况相互交织在一起，被称为代谢综合征，损害了人类的生活质量和生命。Notch信号转导通路是细胞间交流和发育的关键信号转导途径，近年来被认为是新陈代谢中的关键因素。本文综述了Notch信号在调节不同类型细胞或组织代谢中的作用，重点介绍了以该信号轴为靶点治疗代谢性疾病的潜在分子机制。
Evolutionarily unprepared for modern high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to metabolic disorders such as obesity, type 2 diabetes, nonalcoholic fatty liver, and cardiovascular diseases. These metabolic conditions are intertwined, together known as metabolic syndrome, to compromise human life quality as well as lives. Notch signaling, a fundamental signal transduction pathway critical for cell-cell communication and development has recently been recognized as a key player in metabolism. This review summarizes the emerging roles of Notch signaling in regulating metabolism of various cell or tissue types, with emphasis on the underlying molecular mechanisms and potentials of targeting this signal axis to treat metabolic diseases.