Correlation between physical performance and fatigue in cancer patients
Correlation between physical performance and fatigue in cancer patients
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DOI：
10.1023/a:1008234310474
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发表时间：
1997-12-01
影响因子：
50.5
通讯作者：
Keul, J
中科院分区：
文献类型：
--
作者：
Dimeo, F;Stieglitz, RD;Keul, J
背景资料。疲劳和体能下降是癌症患者常见的、往往是严重的问题，无论疾病分期和治疗方式如何。然而，虽然通过实验室测试可以客观地评估身体表现，但疲劳是一种主观现象，其感知受到过去经验和对未来的预期的影响。患者和方法：为了评估疲劳与身体损伤之间的相关性，我们用跑步机测试评估了最大体能，并用两份问卷--情绪状态量表(POMS)和症状自评量表(SCL-90-R)对连续78例癌症实体瘤或血液系统恶性肿瘤患者的心理状态进行了评估。结果：疲倦与最大体能表现之间存在弱相关性(r=-0.30；P<；0.01)。然而，疲劳强度与抑郁(r=0.68)、躯体化(r=0.64)、焦虑(r=0.63；P均<0.001)等心理困扰指标有较强的相关性。此外，躯体运动水平低的癌症患者在抑郁(P=0.005.0 5)、躯体化(P=0.0 3)和焦虑(P=0.0 8)上的得分显著高于体能水平高的癌症患者，而活力(P=0.0 5)的得分显著低于体能水平高的癌症患者。此外，体能低下可以被视为癌症患者精神痛苦的独立预测因素。
Background. Fatigue and a reduction in physical ability are common and often severe problems of cancer patients regardless of disease stage and modality of treatment. However, while physical performance can be assessed objectively with laboratory tests, fatigue is a subjective phenomenon whose perception is influenced by past experience and expectations for the future.Patients and methods: To evaluate the correlation between fatigue and physical impairment, we assessed maximal physical performance with a treadmill test, and mental state with two questionnaires, the Profile of Mood States (POMS) and the Symptom Check List (SCL-90-R), in a successive series of 78 cancer patients with solid tumors or hematological malignancies.Results: A weak association between fatigue and maximal physical performance was found (r = -0.30; P < 0.01). However, intensity of fatigue showed a strong correlation with several indicators of psychological distress such as depression (r = 0.68), somatization (r = 0.64) and anxiety (r = 0.63; P for all < 0.001). Furthermore, patients with lower levels of physical performance had significantly higher scores for depression (P = 0.005), somatization (P = 0.03) and anxiety (P = 0.08), and significantly lower scores for vigor (P = 0.05) than their counterparts whose physical performance was higher.Conclusions: We conclude that fatigue in cancer patients may be related to mood disturbance but appears to be independent of physical performance. Moreover, low physical performance can be viewed as an independent predictor of mental distress in cancer patients.