Maternal Postpartum Depression Increases Vulnerability for Toddler Behavior Problems through Infant Cortisol Reactivity.
Maternal Postpartum Depression Increases Vulnerability for Toddler Behavior Problems through Infant Cortisol Reactivity.
复制标题
母亲产后抑郁症通过婴儿皮质醇反应增加幼儿行为问题的脆弱性。
DOI：
10.1111/infa.12271
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Muzik,Maria
中科院分区：
文献类型：
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作者：
Lawler,JamieM;Bocknek,ErikaL;McGinnis,EllenW;Martinez-Torteya,Cecilia;Rosenblum,KatherineL;Muzik,Maria
目前的研究探讨了婴儿早期下丘脑-垂体-肾上腺反应性（压力的生理指标）作为母亲产后抑郁症和幼儿行为问题之间关系的中介作用。参与者为 137 名高危母亲及其子女，参与了风险代际传播的纵向研究。在婴儿出生后的前 18 个月内，对母亲的抑郁程度进行了五次测量。婴儿皮质醇是在婴儿 6 个月大时在社会压力源（静止面孔范式）下收集的，母亲报告了幼儿在 18 个月大时的内化和外化症状。在这个高风险母婴二人组样本中，早期产后抑郁症预示着 6 个月大的婴儿皮质醇反应不典型，这介导了母亲抑郁症对幼儿行为问题增加的影响。讨论了临床意义。
The current study examined the role of hypothalamic‐pituitary‐adrenal reactivity (a physiological indicator of stress) in early infancy as a mediator of the relationship between maternal postpartum depression and toddler behavior problems. Participants were 137 at‐risk mothers and their children participating in a longitudinal study of intergenerational transmission of risk. Mothers’ depression was measured five times during the infants’ first 18 months. Infant cortisol was collected during a social stressor (the still‐face paradigm) when infants were 6 months old, and mothers reported on toddlers’ internalizing and externalizing symptoms at 18 months. Among this sample of high‐risk mother–infant dyads, early postpartum depression predicted atypical infant cortisol reactivity at 6 months, which mediated the effect of maternal depression on increased toddler behavior problems. Clinical implications are discussed.