Mouse brain organization revealed through direct genome-scale TF expression analysis
Mouse brain organization revealed through direct genome-scale TF expression analysis
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DOI：
10.1126/science.1104935
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发表时间：
2004-12-24
期刊：
影响因子：
56.9
通讯作者：
Ma, QF
中科院分区：
文献类型：
--
作者：
Gray, PA;Fu, H;Ma, QF
在发育中的大脑中，转录因子（TFS）指导形成各种神经元和神经胶质的阵列。我们在小鼠基因组中鉴定了1445个假定的TF。我们使用原位杂交来绘制发育中的小鼠大脑中1000多种TFS和TF-核调节剂基因的表达。我们发现，这些基因中有349个表现出受限的表达模式，足以描述大脑的解剖组织。我们在可搜索的大脑图集数据库中提供了鼠TFS及其表达模式的全面清单。
In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identified 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.