Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.
Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.
复制标题
血管生成抑制剂 O-(氯乙酰基-氨基甲酰基)烟曲霉醇 (AGM-1470) 对大鼠骨肉瘤生长和肺转移的功效。
DOI：
10.1093/oxfordjournals.jjco.a039744
复制
发表时间：
1995
影响因子：
2.4
通讯作者：
Yoichi Konishi
中科院分区：
文献类型：
--
作者：
T. Morishita;Y. Mii;Y. Miyauchi;S. Miura;K. Honoki;M. Aoki;Akira Kido;S. Tamai;Masahiro Tsutsumi;Yoichi Konishi
抗血管生成剂O-（氯乙酰-氨基甲酰）福马吉尔尔（AGM-1470）对原发肿瘤生长和自发性肺转移的抑制作用在我们实验室建立的可移植骨肉瘤大鼠身上进行了实验评估。携带高转移可能性肿瘤的雄性Fischer 344大鼠接受间歇性或连续皮下注射AGM-1470。两种治疗方案均能显著抑制自发性肺转移和原发肿瘤生长，且呈剂量依赖性，其中持续给药AGM-1470对这两个参数的抑制作用最为显著。
The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters.