Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters.
Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters.
复制标题
I型干扰素反应基因在已建立的类风湿关节炎中的表达与临床参数无关。
DOI：
10.1186/s13075-016-1191-y
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发表时间：
2016-12-12
影响因子：
4.9
通讯作者：
Verweij CL
中科院分区：
文献类型：
--
作者：
de Jong TD;Blits M;de Ridder S;Vosslamber S;Wolbink G;Nurmohamed MT;Verweij CL
类风湿性关节炎(RA)患者的外周血干扰素(干扰素)特征(即I型干扰素反应基因[IRG]表达升高)已被描述。在本研究中，我们系统地评估了这种IRG表达与临床参数之间的关系。检测182例类风湿关节炎患者外周血中19种IRGS的表达，并将其平均为干扰素评分。对完整患者组进行相关分析和非配对分析。通过使用一种算法将患者组随机分成两个大小相等的组1000次，然后对这两组进行分析，对分析进行了内部验证。评估干扰素评分与病程、28关节疾病活动性评分及其组成部分、糜烂和结节的发生、自身抗体阳性和免疫抑制治疗之间的关系。这项分析显示，使用羟氯喹、强的松和/或柳氮磺吡啶的患者干扰素评分较低，但其他参数与干扰素评分之间没有显著相关性。选择没有接受羟氯喹、强的松和/或柳氮磺吡啶治疗的患者(n = 95)也没有显示出任何显著的相关性。强的松、羟氯喹和/或柳氮磺吡啶免疫抑制治疗对RA患者IRG表达有影响，但与其他临床参数无明显相关性。因此，干扰素签名似乎描述了RA患者的一个亚组，但似乎不能反映疾病的活动性。本文的在线版本(doi：10.1186/s130750161191-y)包含补充材料，授权用户可以使用。
A peripheral blood interferon (IFN) signature (i.e., elevated type I interferon response gene [IRG] expression) has been described in a subset of patients with rheumatoid arthritis (RA). In the present study, we systematically assessed the association between this IRG expression and clinical parameters. Expression of 19 IRGs was determined in peripheral blood from 182 consecutive patients with RA and averaged into an IFN score per individual. Correlation and unpaired analyses were performed on the complete patient group. The analyses were internally validated by using an algorithm to randomize the patient group 1000 times into two equally sized sets, and then analyses were performed on both sets. Associations were assessed between IFN score and disease duration, 28-joint Disease Activity Score and its components, the occurrence of erosions and nodules, autoantibody positivity, and immunosuppressive treatment. This analysis revealed lower IFN scores in patients using hydroxychloroquine, prednisone, and/or sulfasalazine, but it did not show significant associations between the other parameters and the IFN score. Selecting patients who were not treated with hydroxychloroquine, prednisone, and/or sulfasalazine (n = 95) did not reveal any significant associations either. IRG expression in RA is affected by immunosuppressive treatment with prednisone, hydroxychloroquine, and/or sulfasalazine, but it is not evidently associated with other clinical parameters. Hence, the IFN signature appears to describe a subgroup of patients with RA but does not seem to reflect disease activity. The online version of this article (doi:10.1186/s13075-016-1191-y) contains supplementary material, which is available to authorized users.
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影响因子：
4.9
作者：
Raterman HG;Vosslamber S;de Ridder S;Nurmohamed MT;Lems WF;Boers M;van de Wiel M;Dijkmans BA;Verweij CL;Voskuyl AE
通讯作者：
Voskuyl AE
影响因子：
5.5
作者：
Cantaert, Tineke;van Baarsen, Lisa G.;Baeten, Dominique L.
通讯作者：
Baeten, Dominique L.
影响因子：
5
作者：
van der Pouw Kraan, T. C. T. M.;van Baarsen, L. G. M.;Verweij, C. L.
通讯作者：
Verweij, C. L.
影响因子：
4.9
作者：
de Jong TD;Lübbers J;Turk S;Vosslamber S;Mantel E;Bontkes HJ;van der Laken CJ;Bijlsma JW;van Schaardenburg D;Verweij CL
通讯作者：
Verweij CL
影响因子：
3.7
作者：
Bacher, Nicole;Graulich, Edith;Steinbrink, Kerstin
通讯作者：
Steinbrink, Kerstin