Reproductive experience reduces the sedative, but not anxiolytic effects of diazepam
Reproductive experience reduces the sedative, but not anxiolytic effects of diazepam
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DOI：
10.1016/j.psyneuen.2006.05.008
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发表时间：
2006-09-01
影响因子：
3.7
通讯作者：
Bridges, Robert S.
中科院分区：
文献类型：
--
作者：
Byrnes, Elizabeth M.;Bridges, Robert S.
苯二氮卓类药物经常被用于女性，因为它们具有抗焦虑和催眠作用。先前对啮齿动物的研究表明，生殖经历（即怀孕和哺乳）可以改变对某些药物（例如吗啡）的敏感性。本研究的目的是确定生殖经历是否会改变对苯二氮卓类药物地西泮的敏感性。产生了两组受试者：初产组（怀孕+21天哺乳期）和年龄匹配的未产组。所有受试者在初产雌性断奶后至少 6 周注射地西泮（0.0、0.5、2.0 或 2.5mg/kg）。注射后二十分钟，将受试者置于活动室中并测量运动行为。注射后三十分钟，受试者在自动高架十字迷宫上进行测试。除了行为测试之外，还测量了地西泮对皮质酮水平的影响。总体而言，与在活动室和高架十字迷宫中测定的未产对照相比，初产雌性中地西泮对运动活动的镇静作用显着降低。然而，生殖经历对地西泮在高架十字迷宫中的抗焦虑作用没有显着影响。最后，白色地西泮会增加两组的皮质酮，初产雌性对该药物对皮质酮分泌的影响不太敏感。这些结果表明，地西泮对运动活动和皮质酮分泌的影响在生殖经历后减弱。 (c) 2006 Elsevier Ltd. 保留所有权利。
Benzodiazepines are frequently prescribed to women for both their anxiolytic and hypnotic effects. Previous studies in rodents have demonstrated reproductive experience, i.e. pregnancy and lactation, can alter sensitivity to certain drugs, such as morphine. The purpose of the present study was to determine whether reproductive experience alters sensitivity to the benzodiazepine, diazepam. Two groups of subjects were generated, a primparous group (pregnancy+21 days of lactation) and an age-matched, nulliparous group. All subjects were injected with diazepam (0.0, 0.5, 2.0 or 2.5mg/kg) at least 6 weeks after primiparous females weaned their titters. Twenty minutes post-injection, subjects were place in an activity chamber and locomotor behavior was measured. Thirty minutes post-injection, subjects were tested on an automated elevated plus maze. In addition to behavioral testing, diazepam's effects on corticosterone levels were measured. Overall, diazepam's sedative effects on locomotor activity were significantly reduced in primiparous females when compared to nulliparous controls as determined both in the activity chamber and on the elevated plus maze. There was, however, no significant effect of reproductive experience on the anxiolytic effects of diazepam in the elevated plus maze. Finally, white diazepam increased corticosterone in both groups, primiparous females were less sensitive to the effects of the drug on corticosterone secretion. These results indicate that the effects of diazepam on locomotor activity and corticosterone secretion are attenuated following reproductive experience. (c) 2006 Elsevier Ltd. All rights reserved.