RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria
RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria
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DOI：
10.1101/gad.2030311
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发表时间：
2011-02-15
影响因子：
10.5
通讯作者：
Aiba, Hiroji
中科院分区：
文献类型：
--
作者：
Morita, Teppei;Aiba, Hiroji
一类主要的细菌小rna (sRNAs)，连同rna结合蛋白Hfq和核糖核酸内切酶RNase E，通过碱基配对作用于靶mrna，导致mrna的翻译抑制和快速降解。在这一期的《基因与发育》中，Prevost和他的同事（第385-396页）通过使用表征良好的sRNA RyhB证明，RNase E在配对区域远端的切割会触发目标mrna的降解。该研究为srna诱导的靶mrna降解的初始事件提供了重要的见解。
A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prevost and colleagues (pp. 385-396) demonstrate by using the well-characterized sRNA RyhB that RNase E cleavage at sites distal from the pairing region triggers degradation of target mRNAs. The study has provided an important insight into the initial events of sRNA-induced degradation of target mRNAs.