Phosphine-catalyzed [4 + 2] cyclization of para-quinone methide derivatives with allenes.
Phosphine-catalyzed [4 + 2] cyclization of para-quinone methide derivatives with allenes.
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DOI：
10.1039/c8ob02979b
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发表时间：
2019-02
影响因子：
3.2
通讯作者：
Fu-Ru Yuan;Fei Jiang;Ke-Wei Chen;Guang-Jian Mei;Qiongsi Wu;F. Shi
中科院分区：
文献类型：
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作者：
Fu-Ru Yuan;Fei Jiang;Ke-Wei Chen;Guang-Jian Mei;Qiongsi Wu;F. Shi
对苯二酚（p-QM）衍生物通过磷化氢催化与烯基化合物建立了第一个[4 + 2]环化反应，得到了一系列高收率（高达97%）和优异（E/Z）选择性（均为>95:5 E/Z）的对醌衍生物。该反应不仅丰富了p-QM衍生物环化反应的研究内容，而且为烯烯和膦催化在环化反应中的应用提供了一个很好的例子。此外，该方法也为铬蛋白支架的构建提供了一种有用的方法。
The first [4 + 2] cyclization of para-quinone methide (p-QM) derivatives with allenes has been established via phosphine catalysis, which afforded a series of chroman derivatives in high yields (up to 97%) and excellent (E/Z)-selectivities (all >95 : 5 E/Z). This reaction will not only enrich the research contents of cyclization reactions involving p-QM derivatives, but also provide a good example of the application of allenes and phosphine catalysis in cyclization reactions. In addition, this approach also offers a useful method for the construction of chroman scaffolds.