Energy economy hampers body weight loss after gastric bypass
Energy economy hampers body weight loss after gastric bypass
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DOI：
10.1210/jc.85.12.4695
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发表时间：
2000-12-01
影响因子：
5.8
通讯作者：
Golay, A
中科院分区：
文献类型：
--
作者：
Bobbioni-Harsch, E;Morel, P;Golay, A
对20例接受Roux-en-Y胃旁路治疗的肥胖妇女进行了能量经济对体重减轻的影响研究。静息能量消耗（REE）、底物氧化率、血浆葡萄糖、游离脂肪酸、胰岛素和瘦素水平在手术前、手术后3、6和12个月进行测量。通过对85名体重指数在20至60 kg/m之间的女性的REE和无脂质量进行线性回归分析，获得了预测的REE(2)。以每位患者12个月的曲线下面积（AUC）计算的REE与预测值的偏差被认为是能源经济性的表达。术后12个月内，能量经济AUC与体重下降呈显著负相关（P < 0.005）。能量摄入，根据自我报告的食物消耗计算，也表示为AUC。能量摄入AUC与体重减轻呈显著正相关（P < 0.002）。脂质氧化率（也计算为AUG）与能量经济性呈显著负相关（P < 0.001），与能量摄入量呈显著正相关（P < 0.002）。术前瘦素值与个体能量经济能力显著相关（P < 0.01）。综上所述，Roux-en-Y胃旁路手术后，能量经济性可能通过低脂肪氧化率阻碍了减肥过程。
The impact of energy economy on body weight loss was investigated in 20 obese women, submitted to Roux-en-Y gastric bypass. Resting energy expenditure (REE), substrate oxidation rates, plasma glucose, free fatty acid, and insulin and leptin levels were measured before and 3, 6, and 12 months after surgery. Predicted REE was obtained from linear regression analysis of REE and fat free mass, in a group of 85 women, whose body mass index ranged between 20 and 60 kg/m(2). The deviation from predicted REE, calculated as area under the curve (AUC) over the 12-month period for each patient, was considered as the expression of energy economy. Energy economy AUC was significantly (P < 0.005) negatively related to the weight lost during 12 months after surgery.Energy intake, calculated from self-reported food consumption, was also expressed as AUC. Energy intake AUC showed a significant (P < 0.002) positive correlation with weight loss.Lipid oxidation rate, also calculated as AUG, significantly correlated, negatively, with energy economy (P < 0.001) and, positively, with energy intake (P < 0.002). Preoperative leptin values were significantly (P < 0.01) linked to individual energy economy capacity.In conclusion, after Roux-en-Y gastric bypass, energy economy hampers the weight loss process, probably through a low fat oxidation rate.