The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor.
The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor.
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DOI：
10.5551/jat.11.200
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发表时间：
2004
影响因子：
4.4
通讯作者：
Sadao Takahashi;J. Sakai;T. Fujino;H. Hattori;Y. Zenimaru;J. Suzuki;I. Miyamori;Tokuo T. Yamamoto
中科院分区：
文献类型：
--
作者：
Sadao Takahashi;J. Sakai;T. Fujino;H. Hattori;Y. Zenimaru;J. Suzuki;I. Miyamori;Tokuo T. Yamamoto
极低密度脂蛋白（VLDL）受体是低密度脂蛋白（LDL）受体家族的一员。体外和体内研究表明，VLDL受体与富含甘油三酯（TG）的脂蛋白结合，而不与LDL结合，并作为外周残余脂蛋白受体发挥作用。VLDL受体在脂肪酸活性组织（心脏、骨骼肌和脂肪）、大脑和巨噬细胞中大量表达。VLDL受体可能与脂蛋白脂肪酶（LPL）协同作用，后者水解VLDL和乳糜微粒中的TG。与LDL受体不同，VLDL受体结合载脂蛋白（apo） E2/2 VLDL颗粒以及apoE3/3 VLDL，且其表达不受细胞内脂蛋白的下调。近年来，VLDL受体在脂蛋白代谢、代谢综合征/动脉粥样硬化、心脏脂肪酸代谢、神经元迁移和血管生成/肿瘤生长等方面的各种功能被报道。肝内VLDL受体基因治疗对LDL受体敲除和apoE突变小鼠的脂蛋白代谢均有有益作用。除了作为外周脂蛋白受体的功能外，其生理功能的可能性已扩展到包括信号转导，血管生成和肿瘤生长。
The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. In vitro and in vivo studies have shown that VLDL receptor binds triglyceride (TG)-rich lipoproteins but not LDL, and functions as a peripheral remnant lipoprotein receptor. VLDL receptor is expressed abundantly in fatty acid-active tissues (heart, skeletal muscle and fat), the brain and macrophages. It is likely that VLDL receptor functions in concert with lipoprotein lipase (LPL), which hydrolyses TG in VLDL and chylomicron. In contrast to the LDL receptor, VLDL receptor binds apolipoprotein (apo) E2/2 VLDL particles as well as apoE3/3 VLDL, and the expression is not down-regulated by intracellular lipoproteins. Recently, various functions of the VLDL receptor have been reported in lipoprotein metabolism, metabolic syndrome/atherosclerosis, cardiac fatty acid metabolism, neuronal migration and angiogenesis/tumor growth. Gene therapy of VLDL receptor into the liver showed a benefit effect for lipoprotein metabolism in both LDL receptor knockout and apoE mutant mice. Beyond its function as a peripheral lipoprotein receptor, possibilities of its physiological function have been extended to include signal transduction, angiogenesis and tumor growth.