The prevalence of depression in hereditary spastic paraplegia
The prevalence of depression in hereditary spastic paraplegia
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DOI：
10.1177/0269215509337186
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发表时间：
2009-09-01
影响因子：
3
通讯作者：
Gross-Paju, K.
中科院分区：
文献类型：
--
作者：
Vahter, L.;Braschinsky, M.;Gross-Paju, K.
目的：评价抑郁症的患病率及单项访谈“你抑郁吗？”的敏感性和特异性。设计：单项访谈你抑郁吗？作为抑郁症的筛选问题;所有参与者然后完成Beck抑郁量表。设置：从流行病学数据库中识别出的遗传性痉挛性截瘫患者，他们同意参加研究。主要测量：Beck抑郁量表，临床访谈。结果：流行病学数据库包括59例临床确诊为遗传性痉挛性截瘫的患者。其中48人同意参加这项研究。Beck抑郁量表评分高于临界点者占58%（28/48），低于临界点者占42%（20/48）。在研究组中，44%（21/48）有轻度抑郁，13%（6/48）有中度抑郁，1人表现为重度抑郁。贝克抑郁量表评分与活动水平之间存在统计学显著相关性;未检测到与其他措施的其他显著相关性。在参与者中，54%（26/48）的人对抑郁症有主观抱怨，并对单项访谈“你抑郁吗？”'.遗传性痉挛性截瘫组单项访谈的敏感性为75%，特异性为75%。结论：遗传性痉挛性截瘫患者普遍存在轻度抑郁。虽然单一的问题可能是有帮助的，但在评估一个人的抑郁症时不能完全依赖它。
Objective: To evaluate the prevalence of depression and sensitivity and specificity of the single-item interview 'Are you depressed?' for people with hereditary spastic paraplegia in Estonia.Design: Single-item interview 'Are you depressed?' was used as a screening question for depression; all participants then completed the Beck Depression Inventory.Setting: People with hereditary spastic paraplegia identified from the epidemiological database who agreed to participate in the study.Main measures: Beck Depression Inventory, clinical interview.Results: The epidemiological database consisted of 59 patients with clinically confirmed diagnosis of hereditary spastic paraplegia. Forty-eight of these consented to participate in the study. The Beck Depression Inventory score was higher than cut-off point in 58% (28/48) and lower in 42% (20/48). Of the study group, 44% (21/48) had mild, 13% (6/48) moderate and one person revealed severe depression. There was a statistically significant correlation between Beck Depression Inventory score and level of mobility; no other significant correlations with other measures were detected. Of the participants, 54% (26/48) had subjective complaints about depression and answered 'Yes' to the single-item interview 'Are you depressed?'. The sensitivity of the one-item interview in the hereditary spastic paraplegia group was 75% and specificity 75%.Conclusions: Our results show that mild depression is prevalent among people with hereditary spastic paraplegia. Although the single question may be helpful, it cannot be relied upon entirely when assessing a person for depression.