ANAL CANCER IN WOMEN
ANAL CANCER IN WOMEN
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DOI：
10.1016/0016-5085(88)90297-1
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发表时间：
1988-07-01
期刊：
影响因子：
29.4
通讯作者：
HOLMES, G
中科院分区：
文献类型：
--
作者：
HOLMES, F;BOREK, D;HOLMES, G
我们研究了 56 名患有肛门癌的女性的诱发因素，并将她们与从人群中抽取的 56 名匹配对照进行比较。在结构化访谈中向每个研究对象发放详细的预测试问卷，并抽血通过放射免疫分析检测单纯疱疹病毒抗体。获取了病例的病理材料并寻找人乳头瘤病毒感染的证据。通过单变量分析，发现肛门癌与单纯疱疹病毒 2 滴度阳性 (p = 0.0017)、吸烟 (p = 0.0028)、既往宫颈巴氏涂片阳性或可疑 (p = 0.0124) 以及性伴侣数量增加 (p = 0.0224) 之间存在关联。通过逻辑回归的多变量技术，发现与吸烟（p = 0.0126）、既往使用痔疮制剂（p = 0.0149）以及> 1个月的排便习惯紊乱史（p = 0.0273）存在独立且显着的关联。女性肛门癌是一种罕见的疾病，与吸烟和性经历有关。其与既往肛门直肠疾病的关联尚不清楚，值得进一步研究。
We studied predisposing factors in 56 women with anal cancer, comparing them with 56 matched controls drawn from the population. A detailed pretested questionnaire was administered to each study subject in a structured interview and blood was drawn for detection of herpes simplex virus antibodies by radioimmunoassay. Pathologic material from cases was obtained and evidence of human papilloma virus infection was sought. By univariate analyses were found associations between anal cancer and positive herpes simplex virus 2 titer (p = 0.0017), cigarette smoking (p = 0.0028), previous positive or questionable cervical Papanicolaou smear (p = 0.0124), and increasing number of sexual partners (p = 0.0224). By the multivariate technique of logistic regression there were independent and significant associations with cigarette smoking (p = 0.0126), previous use of hemorrhoid preparations (p = 0.0149), and history of disturbed bowel habits for > 1 mo (p = 0.0273). Anal cancer in women is a rare disease associated with cigarette smoking and sexual experience. Its association with previous anorectal disease is unclear and deserving of further study.