Review: Annexin-A5 and cell membrane repair
Review: Annexin-A5 and cell membrane repair
复制标题
DOI：
10.1016/j.placenta.2015.01.193
复制
发表时间：
2015-04-01
期刊：
影响因子：
3.8
通讯作者：
Brisson, A. R.
中科院分区：
文献类型：
--
作者：
Bouter, A.;Carmeille, R.;Brisson, A. R.
膜联蛋白是一种可溶性蛋白质，它以钙离子依赖的方式结合到含有负电荷的磷脂，主要是磷脂酰丝氨酸的生物膜上。膜联蛋白-A5(Annexin-A5，AnxA5)是膜联蛋白家族中最小的成员，具有独特的膜结合和自组装特性，可在膜表面形成有序的二维阵列。我们之前已经报道过AnxA5在膜修复机制中发挥核心作用，它使小鼠血管周围细胞的质膜破裂能够快速重新密封。AnxA5通过在膜损伤部位形成保护性2D绷带来促进膜修复。在这里，我们回顾了目前关于细胞膜修复的知识，并介绍了AnxA5在人滋养层细胞膜再密封中的作用的最新发现。(C)IFPA和爱思唯尔有限公司出版的2015年。
Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca2+-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dimensional (2D) arrays on membrane surfaces. We have previously reported that AnxA5 plays a central role in the machinery of membrane repair by enabling rapid resealing of plasma membrane disruption in murine perivascular cells. AnxA5 promotes membrane repair via the formation of a protective 2D bandage at membrane damaged site. Here, we review current knowledge on cell membrane repair and present recent findings on the role of AnxA5 in membrane resealing of human trophoblasts. (C) 2015 Published by IFPA and Elsevier Ltd.