Colorimetric chiral discrimination of lysine enantiomers and configurable logic gate operation based on fluorescein-functionalized polydiacetylene vesicles
Colorimetric chiral discrimination of lysine enantiomers and configurable logic gate operation based on fluorescein-functionalized polydiacetylene vesicles
复制标题
基于荧光素功能化聚二乙炔囊泡的赖氨酸对映体的比色手性辨别和可配置逻辑门操作
DOI：
10.1039/c9ay02518a
复制
发表时间：
2020-02-07
影响因子：
3.1
通讯作者：
Li, Bin
中科院分区：
文献类型：
--
作者：
Yang, Guang;Ji, Jie;Li, Bin
氨基酸对映体的手性识别具有重要意义，因为l型氨基酸是蛋白质分子结构的基本手性元素。本研究开发了一种基于荧光素取代聚二乙炔（FPDA）囊泡的新型简单比色手性传感器。由于它们与Cu2+离子、FPDA囊泡和赖氨酸对映体的络合能力不同，上述杂化PDA囊泡传感器可以实现赖氨酸的实际手性识别。此外，在pH、Cu2+离子、D-赖氨酸或l -赖氨酸等参数的刺激条件下，混合FPDA囊泡成功构建了两个基本的“与”和“或”逻辑运算。这些基于比色共轭聚合物的逻辑门操作可以识别手性对映体，可能为复杂微环境下的手性传感和信息存储提供新的机会。
The chiral recognition of amino acid enantiomers is of great significance owing to the fact that L-type amino acids act as the basic chiral elements of the molecular architecture of proteins. In this study, a novel and simple colorimetric chiral sensor based on fluorescein-substituted polydiacetylene (FPDA) vesicles was developed. Due to their different complexing abilities with Cu2+ ions, FPDA vesicles and lysine enantiomers, the above hybrid PDA vesicle sensors allow practical chiral discrimination of lysine. Moreover, with two defined stimulus conditions from each of the parameters pH, Cu2+ ion, D- or L-lysine, the hybrid FPDA vesicles were used to construct two basic “AND” and “OR” logic operations successfully. These logic gate operations, which are based on colorimetric conjugated polymers and can discriminate chiral enantiomers, may provide new opportunities for chiral sensing and information storage in complicated microenvironments.