Variation and repeatability of measured standardized uptake values depending on actual values: a phantom study.
Variation and repeatability of measured standardized uptake values depending on actual values: a phantom study.
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测量的标准化摄取值的变化和重复性取决于实际值：一项幻影研究。
DOI：
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发表时间：
2017
影响因子：
2.5
通讯作者：
Tomio Inoue
中科院分区：
文献类型：
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作者：
T. Kaneta;N. Sun;Matsuyoshi Ogawa;Hitoshi Iizuka;T. Arisawa;Ayako Hino;Keisuke Yoshida;Tomio Inoue
标准化摄取值（SUVs）是正电子发射断层扫描（PET）中应用最广泛的定量成像生物标志物；然而，对于suv的变化和可重复性取决于数值的大小的变化知之甚少。我们假设低suv比高suv有更大的变化，并尝试使用幻影进行各种实验性PET扫描。通过调整F-18溶液与自来水的比例，在6个热球体内设置了2.0、4.0和8.0的NEMA IEC车身幻影。PET数据采集4小时，每2分钟重建一次。记录了所有图像中球体的SUVmax和SUVpeak。用实测SUV除以实际SUV计算相对SUV，并用于Bland-Altman图。在测量的suv中观察到一些变化。2.0的实测SUV在2.0、4.0、8.0中差异最大，8.0最小。同样，相对的suv在较低的值上显示出明显更大的变化。相对SUVmax比相对SUVpeak表现出更大的变化和值。Bland-Altman图显示出较大的差异，但差异程度随测量值的增加而减小。我们展示了测量suv的一些变化，测量值越大，测量值越低。临床医生不仅应该在日常实践中考虑低suv的不准确性，而且应该在多机构研究中考虑。
Standardized uptake values (SUVs) are the most widely used quantitative imaging biomarkers in positron emission tomography (PET); however, little is known about the changes in variation and repeatability of SUVs depending on the magnitude of the values. We hypothesized that low SUVs have larger variations than high SUVs, and attempted various kinds of experimental PET scans using a phantom. By adjusting the ratio of F-18 solution to tap water, a NEMA IEC body phantom was set for SUVs of 2.0, 4.0, and 8.0 inside six hot spheres. PET data were obtained for 4 hours, and the data reconstructed every 2 min. The SUVmax and SUVpeak of the spheres in all images were recorded. The relative SUVs were calculated by dividing the measured SUV by actual SUV, and used for the Bland-Altman plots. Some variation was observed for the measured SUVs. The measured SUVs for the actual SUV of 2.0 showed the largest variation among those of 2.0, 4.0, and 8.0, and those of 8.0 showed the smallest. Similarly, the relative SUVs showed significantly larger variations for lower values. In addition, the relative SUVmax showed larger variation and value than the relative SUVpeak. The Bland-Altman plots showed considerable variation and little agreement, but the degree of variation decreased as the measured value increased. We demonstrated some variation of the measured SUVs, which decreased for larger measured values. Clinicians should consider the inaccuracy of low SUVs not only in daily practice, but also for multi-institutional studies.
乳腺癌 (18)F-FDG PET 注射后 SUV 随时间变化：表征和调整时间差异的方法。
DOI：
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发表时间：
2003
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Beaulieu,Sylvain;Kinahan,Paul;Tseng,Jeffrey;Dunnwald,LisaK;Schubert,ErinK;Pham,Pam;Lewellen,Barbara;Mankoff,DavidA
通讯作者：
Mankoff,DavidA