Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.
Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.
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在社区居住的多种族队列中表征血浆NFL：Hable研究的结果。
DOI：
10.1002/alz.12404
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发表时间：
2022-03
期刊：
影响因子：
--
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中科院分区：
文献类型：
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尚未在不同人群中进行神经丝轻链 (NfL) 的大规模表征。基线数据的分析来自拉丁裔老年人多种族健康与老龄化大脑 (HABLE) 研究，其中包括 890 名墨西哥裔美国人和 813 名非西班牙裔白人。血浆 NfL 在 Simoa 平台上测量。在未经调整的模型中，NfL 与年龄 (P < .001)、高血压 (P < .001)、血脂异常 (P = .02) 和糖尿病 (P < .001) 显着相关。在现有数据的子集中，随着年龄和性别的变化，NfL 与神经退行性变 (P < .001) 和整体淀粉样蛋白负荷水平 (P = .02) 相关。 NfL 水平与诊断组显着相关（正常认知 [NC]、轻度认知障碍 [MCI]、痴呆；P < .001）；然而，没有任何分数可以产生可接受的诊断准确性。 NfL 水平的灵敏度为 0.60，特异性为 0.78，检测淀粉样蛋白阳性的阴性预测值为 89%。血浆 NfL 水平受到年龄和老年人中常见的合并症的显着影响，这使其作为诊断生物标志物的用途变得复杂
No large‐scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non‐Hispanic Whites from the multi‐ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. In unadjusted models, NfL was significantly associated with age (P < .001), hypertension (P < .001), dyslipidemia (P = .02), and diabetes (P < .001). Covarying for age and sex, NfL was associated with neurodegeneration (P < .001) and global amyloid burden levels (P = .02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P < .001); however, there was no cut‐score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Plasma NfL levels are significantly impacted by age and medical co‐morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker
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影响因子：
3.7
作者：
Blennow K
通讯作者：
Blennow K
DOI：
10.3233/jad-200901
发表时间：
2021
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Barker W;Quinonez C;Greig MT;Behar R;Chirinos C;Rodriguez RA;Rosselli M;Rodriguez MJ;Cid RC;Rundek T;McFarland K;Hanson K;Smith G;DeKosky S;Vaillancourt D;Adjouadi M;Marsiske M;Ertekin-Taner N;Golde T;Loewenstein DA;Duara R
通讯作者：
Duara R
影响因子：
29
作者：
Mattsson N;Andreasson U;Zetterberg H;Blennow K;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
4
作者：
O'Bryant, Sid E.;Xiao, Guanghua;Barber, Robert
通讯作者：
Barber, Robert
DOI：
10.1186/s13195-018-0404-9
发表时间：
2018-07-28
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Lewczuk P;Ermann N;Andreasson U;Schultheis C;Podhorna J;Spitzer P;Maler JM;Kornhuber J;Blennow K;Zetterberg H
通讯作者：
Zetterberg H