VARIATION OF SENSITIVITY TO IONIZING RADIATION WITH AGE
VARIATION OF SENSITIVITY TO IONIZING RADIATION WITH AGE
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DOI：
10.1038/1831729a0
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发表时间：
1959-01-01
期刊：
影响因子：
64.8
通讯作者：
ROTBLAT, J
中科院分区：
文献类型：
--
作者：
CROSFILL, ML;LINDOP, PJ;ROTBLAT, J
辐射的长期效应与衰老之间的关系近年来一直是大量研究的主题，但对于给定剂量的辐射产生的效应随年龄的变化，几乎没有进行定量研究。使用单剂量，Abrams 1发现4周龄小鼠的死亡率最高。Hursh和Casarett 2测量了不同年龄大鼠的LD 50，发现在生命的后期随着年龄的增长而下降; Sacher 3对小鼠获得了类似的结果。我们正在对辐射对小鼠的长期影响进行系统研究，特别是这些影响对年龄的依赖性。作为这项工作的一部分，我们研究了灵敏度随年龄的变化，作为辐射损伤的标准LD 50在30天。
THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams1found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett2measured theLD50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher3for mice. We are carrying out a systematic study4of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage theLD50 at 30 days.