Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048
Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048
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DOI：
10.1080/09168451.2018.1482195
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发表时间：
2018-01-01
影响因子：
1.6
通讯作者：
Hisa, Keiko
中科院分区：
文献类型：
--
作者：
Matsuzaki, Chiaki;Takagaki, Chikahiro;Hisa, Keiko
本研究旨在探讨肠膜明串珠菌NTM 048菌株分泌的具有解毒活性的胞外多糖（EPS）对骨髓来源的树突状细胞（DC）的免疫刺激作用。EPS刺激增加IL-6、IL-10、IL-12和视网膜脱氢酶（RALDH）基因表达水平，并诱导合成视黄酸的RALDH活性DC，其在控制粘膜中的适应性免疫应答中起至关重要的作用。
This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.