Tumour-regulated anorexia preceding cachexia.
Tumour-regulated anorexia preceding cachexia.
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肿瘤调节的厌食症先于恶病质。
DOI：
10.1038/s41556-021-00635-8
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发表时间：
2021
影响因子：
21.3
通讯作者：
Lyden,David
中科院分区：
文献类型：
--
作者：
Wang,Gang;Zhang,Haiying;Lyden,David
厌食症通常发生于晚期癌症患者，并与恶病质密切相关。一项新的研究表明，在果蝇和小鼠肿瘤模型中，厌食症比恶病质更早出现，并且肿瘤来源的体液因子通过全身性调节大脑神经肽诱导厌食症。
Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in bothDrosophilaand mouse tumour models and that tumour-derived humoral factors induce anorexia by systemically dysregulating neuropeptides in the brain.