Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan
Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan
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植物内生真菌 Pestalotiopsis foedan 的抗真菌代谢物
DOI：
10.1021/np070590f
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发表时间：
2008-04-01
影响因子：
5.1
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
--
作者：
Ding, Gang;Liu, Shuchun;Che, Yongsheng
从拟盘多毛孢（Pestalotiopsis foedan）的固体培养物中分离到一种新的还原螺环氮杂萘酮衍生物-这些化合物的结构主要是通过分析它们的NMR光谱数据来确定的。通过H-1 NMR J值和NOESY数据对化合物1-3的相对构型进行了归属，并利用CD激发手性和改进的Mosher方法确定了化合物1-3的绝对构型.化合物1-3显示出一定的抗真菌活性。
Pestafolide A (1), a new reduced spiro azaphilone derivative, and pestaphthalides A (2) and B (3), two new isobenzofuranones, have been isolated form solid cultures of an isolate of Pestalotiopsis foedan. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configuration of 1-3 was assigned by analysis of H-1 NMR J-values and NOESY data, and the absolute configuration was determined by application of the CD excitation chirality and modified Mosher method. Compounds 1-3 showed modest antifungal activity.