Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs
Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs
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DOI：
10.1007/s00251-018-1066-2
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发表时间：
2018-09-01
期刊：
影响因子：
3.2
通讯作者：
Ewald, Sandra J.
中科院分区：
文献类型：
--
作者：
Kim, Taejoong;Hunt, Henry D.;Ewald, Sandra J.
鸡的主要组织相容性复合体（MHC或B复合体）的I类主要（BF 2）和次要（BF 1）糖蛋白的功能进行比较，他们的表达，提出病毒抗原的细胞毒性T淋巴细胞（CTL）的能力，并与自然杀伤（NK）细胞的相互作用。MHC-限制性CTL在BF 2 *21主要糖蛋白的背景下识别病毒抗原，但不识别BF 1 *21次要糖蛋白。马立克氏病病毒（Marek's disease virus，MDV）是一种能降低细胞表面I类糖蛋白表达的大DNA病毒，其BF 2糖蛋白表达降低，而BF 1糖蛋白表达无变化或略有增加。此外，BF 1 *21 I类糖蛋白的表达保护靶细胞免于NK细胞裂解，而BF 2 *21 I类糖蛋白的表达增强靶细胞的NK细胞裂解。因此，BF 1和BF 2提供两种不同的细胞免疫功能; BF 1负调节NK细胞杀伤活性，BF 2限制抗原特异性CTL免疫应答。
The function of the chicken's major histocompatibility complex (MHC or B complex) class I major (BF2) and minor (BF1) glycoproteins is compared for their expression, ability to present viral antigens to cytotoxic T lymphocytes (CTLs), and interaction with natural killer (NK) cells. MHC-restricted CTLs recognized virus antigen in the context of the BF2*21 major glycoprotein but not the BF1*21 minor glycoprotein. Marek's disease virus (MDV), a large DNA virus known to reduce the cell surface expression of class I glycoprotein, reduced the expression of BF2 glycoprotein while BF1glycoprotein expressions are remained as no change or slight increase. In addition, the expression of BF1*21 class I glycoprotein protected target cells from NK cell lysis while the expression of the BF2*21 class I glycoprotein enhanced NK cell lysis of target cells. Therefore, BF1 and BF2 provide two different cellular immune functions; BF1 negatively regulates the NK cell killing activity and BF2 restricts the antigen specific CTL immune response.