CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE, PRODUCED BY STREPTOMYCES-MELANOSPOROFACIENS MI614-43F2 - TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE, PRODUCED BY STREPTOMYCES-MELANOSPOROFACIENS MI614-43F2 - TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
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DOI：
10.7164/antibiotics.45.1587
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发表时间：
1992-10-01
影响因子：
3.3
通讯作者：
TAKEUCHI, T
中科院分区：
文献类型：
--
作者：
AOYAGI, T;AOYAMA, T;TAKEUCHI, T
环辛丁已从产黑孢链霉菌M1614- 43 F2中分离出来，作为寻找微生物产生的溶血磷脂酶抑制剂的计划的一部分。将其通过硅胶色谱法、Capcell Pak C18（HPLC）和Sephadex LH-20进行纯化，随后进行溶剂萃取，然后分离为无色粉末。环辛锡的分子式为C20 H34 O3。它与底物具有竞争性，抑制常数Ki = 4.8 × 10 ~（-6）M。
Cyclooctatin has been isolated from Streptomyces melanosporofaciens M1614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C18 (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C20H34O3. It is competitive with the substrate, and the inhibition constant (Ki) was 4.8 x 10(-6) M.