Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002
Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002
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DOI：
10.1080/09553000601085980
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发表时间：
2006-12-01
影响因子：
2.6
通讯作者：
Chang, W. P.
中科院分区：
文献类型：
--
作者：
Hwang, S. -L.;Guo, H. -R.;Chang, W. P.
目的：评估台湾地区因使用含钴-60污染钢材的建筑物而受到长达10年的低剂量率照射的人群的癌症风险。材料和方法：采用标准化发病率比(SIR)，对年龄和性别进行调整后，比较台湾地区具有相同时间和地理特征的人群的癌症风险。通过Poisson多元回归分析，进一步评估癌症风险与过量累积暴露之间的关系。结果：共有7271人登记为暴露人群，有101,560人年处于危险之中。平均超额累积暴露约为47.8mSv(范围1-2,363 mSv)。共观察到141名患有各种癌症的暴露者，其中95人分别在最初居住在受污染的建筑物中超过2年或10年后患上白血病或实体癌。除慢性淋巴细胞白血病外，男性所有白血病的SIR均显著升高(n=6，SIR 3.6，95%可信区间[CI]1.2~7.4)，女性甲状腺癌SIR略高(n=6，SIR 2.6，95%CI 1.0~5.7)。另一方面，所有癌症加在一起，所有实体癌症加在一起，显示出在30岁之前首次接触的个体的风险显著增加，但超过这个年龄的个体没有。结论：结果表明，在台湾这一人群的特定亚群中，长期的低剂量率辐射似乎增加了患某些癌症的风险。
Purpose: To assess cancer risks in a population that received prolonged low dose-rate g-irradiation for about 10 years as a result of occupying buildings containing Co-60-contaminated steel in Taiwan.Materials and methods: The cancer risks were compared with those populations with the same temporal and geographic characteristics in Taiwan by standardized incidence ratios (SIR), adjusted for age and gender. The association of cancer risks with excess cumulative exposure was further evaluated for their relative risks by the Poisson multiple regression analysis.Result: A total of 7271 people were registered as the exposed population, with 101,560 person-years at risk. The average excess cumulative exposure was approximately 47.8 mSv (range < 1-2,363 mSv). A total of 141 exposed subjects with various cancers were observed, while 95 developed leukemia or solid cancers after more than 2 or 10 years initial residence in contaminated buildings respectively. The SIR were significantly higher for all leukemia except chronic lymphocytic leukemia (n = 6, SIR 3.6, 95% confidence interval [CI] 1.2-7.4) in men, and marginally significant for thyroid cancers (n = 6, SIR 2.6, 95% CI 1.0-5.7) in women. On the other hand, all cancers combined, all solid cancers combined were shown to exhibit significant exposure-dependent increased risks in individuals with the initial exposure before the age of 30, but not beyond this age.Conclusions: The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.