Osteosarcoma - Anatomic and histologic variants
Osteosarcoma - Anatomic and histologic variants
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DOI：
10.1309/uc6kqhld9lv2kenn
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发表时间：
2006-04-01
影响因子：
3.5
通讯作者：
Siegal, GP
中科院分区：
文献类型：
--
作者：
Klein, MJ;Siegal, GP
骨肉瘤是最常见的骨原发肿瘤，但其在恶性肿瘤中的绝对发病率较低。在严格的组织学定义下，骨肉瘤由一系列病变组成，在组织学特征和分级上具有相当大的多样性。其预后不仅取决于这些参数，还取决于其解剖部位。它可发生在骨内(髓内或皮质内)、骨表面和骨外部位。其诊断或预后意义的信息尚未从其细胞遗传学研究中阐明。本文综述了骨肉瘤的解剖和组织学变异，并提出了骨肉瘤的分类方案。
Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic, definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. Its prognosis is dependent not only on these parameters but also on its anatomic site. It may occur inside the bones (in the intramedullary or intracortical compartment), on the surfaces of bones, and in extraosseous sites. Information of diagnostic or prognostic significance has not been elucidated from studies of its cytogenetics. This review summarizes the anatomic and histologic variations of osteosarcoma and offers a schema for its subclassification.