Prevalence of depression among type 2 diabetes mellitus patients in India: A meta-analysis
Prevalence of depression among type 2 diabetes mellitus patients in India: A meta-analysis
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DOI：
10.1016/j.psychres.2018.09.037
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发表时间：
2018-12-01
影响因子：
11.3
通讯作者：
Najmi, Abul Kalam
中科院分区：
文献类型：
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作者：
Hussain, Salman;Habib, Anwar;Najmi, Abul Kalam
抑郁症作为 2 型糖尿病 (T2DM) 患者的共病，与显着的发病率、死亡率和不断上升的健康经济负担相关。印度医疗保健系统承受着 T2DM 的沉重负担，了解与 T2DM 相关的抑郁症患病率非常重要。该荟萃分析按照注册方案（PROSPERO 注册：CRD42016051552）进行，检索了截至 2018 年 8 月 31 日在 MEDLINE 和 Embase 等数据库中已发表的研究。使用修改后的纽卡斯尔-渥太华量表来评估方法学质量。 T2DM 患者抑郁症的汇总患病率被估计为主要结局，而基于人口亚组的患病率被估计为次要结局。总共有 43 项研究（包括 10,270 名患者）符合资格标准并被纳入分析。 T2DM 患者抑郁症的汇总患病率为 38%（95% CI：31%-45%）。 2 型糖尿病患者的抑郁症通常与并发症的存在相关，优势比为 2.33，95% CI：1.62-3.36，p < 0.00001。总体而言，该研究发现印度 T2DM 患者抑郁症患病率较高。印度的糖尿病管理项目可能会考虑对 T2DM 患者进行抑郁症早期筛查。
Depression as a co-morbid condition in type 2 diabetes mellitus (T2DM) patients is associated with significant morbidity, mortality, and rising health economic burden. Indian healthcare system is heavily burdened with T2DM, and it is important to understand the prevalence of depression associated with T2DM. This meta-analysis conducted as per the registered protocol (PROSPERO registration: CRD42016051552), searched for published studies in the databases including MEDLINE and Embase till 31st August 2018. The modified Newcastle-Ottawa Scale was used to assess the methodological quality. The pooled prevalence of depression among T2DM patients was estimated as primary outcomes, while prevalence based on demographic sub-group was estimated as the secondary outcome. In total, 43 studies including 10,270 patients fulfilled the eligibility criteria and were included in the analysis. The pooled prevalence of depression in T2DM patients was found to be 38% (95% CI: 31%-45%). Presence of depression in people with type 2 diabetes was more often associated with the presence of complications with an odds ratio of 2.33, 95% CI: 1.62-3.36, p < 0.00001. Overall, the study found a high prevalence of depression among T2DM patients in India. Diabetes management programs in India may consider early screening of depression in T2DM patients.