Clinical trial awareness: Changes over time and sociodemographic disparities
Clinical trial awareness: Changes over time and sociodemographic disparities
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DOI：
10.1177/1740774515571917
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发表时间：
2015-06-01
期刊：
影响因子：
2.7
通讯作者：
Galsky, Matthew D.
中科院分区：
文献类型：
--
作者：
Leiter, Amanda;Diefenbach, Michael A.;Galsky, Matthew D.
背景或目的：缺乏临床试验意识是临床试验入组的一个已知障碍。我们试图确定临床试验意识在美国人群中的流行程度，确定与试验意识增加相关的特征，并探索试验意识的潜在差异。方法：采用2008年至2012年健康信息全国趋势调查数据。使用逻辑回归来评估临床试验意识的预测因子，特别是社会人口学变量和信息寻求偏好。在患者亚组和两个时间段之间比较试验意识和信息寻求偏好。结果：临床试验意识从2008年的68%上升到2012年的74%。在2012年的数据集中，高等教育水平（优势比：3.52,95%置信区间：2.16-5.74）、较高的年收入类别（优势比：1.84,95%置信区间：1.17-2.89）和互联网使用（优势比：2.13,95%置信区间：1.52-3.00）与临床试验意识显著相关。西班牙裔（优势比：0.41,95%可信区间：0.25-0.68）与认知下降显著相关。2008年至2012年间，非裔美国人/黑人（10.6%）和西班牙裔美国人（10.7%）的临床试验意识有所提高，两个亚组的互联网使用也有所增加（分别为14.2%和18.1%）。结论：2008年至2012年间，总体临床试验意识有所提高，但仍有很大一部分人群缺乏临床试验的一般意识。在审判意识方面存在种族和民族差异，尽管这种差异在黑人人口中可能正在减少。这些发现可能有助于有针对性的教育工作，并告知提高试验意识的方法。
Background or aims: Lack of clinical trial awareness is a known obstacle to clinical trial enrollment. We sought to define the prevalence of clinical trial awareness in the US population, determine characteristics associated with increased trial awareness, and explore potential disparities in trial awareness.Methods: We utilized data from the Health Information National Trends Survey from 2008 and 2012. Logistic regression was utilized to assess predictors of clinical trial awareness, particularly sociodemographic variables and information-seeking preferences. Trial awareness and information-seeking preferences were compared in patient subgroups and between the two time periods.Results: Clinical trial awareness increased from 68% to 74% between 2008 and 2012. In the 2012 dataset, higher education level (odds ratio: 3.52, 95% confidence interval: 2.16-5.74), higher yearly income category (odds ratio: 1.84, 95% confidence interval: 1.17-2.89), and Internet use (odds ratio: 2.13, 95% confidence interval: 1.52-3.00) were significantly associated with clinical trial awareness. Hispanic ethnicity (odds ratio: 0.41, 95% confidence interval: 0.25-0.68) was significantly associated with decreased awareness. Clinical trial awareness increased in African-American/Blacks (10.6%) and Hispanics (10.7%) between 2008 and 2012, as did Internet use in both subgroups (14.2%, 18.1%, respectively).Conclusion: Overall clinical trial awareness has increased between 2008 and 2012, although a large subset of the population still lacks general awareness of clinical trials. Racial and ethnic disparities in trial awareness exist, although disparities may be decreasing among the Black population. These findings may help target educational efforts and inform approaches to increasing trial awareness.